IRF8 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of IRF8.
Immunogen
A synthetic peptide corresponding to C-terminus 16 amino acids of human IRF8.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of IRF8 in human thymus tissue lysate with IRF8 polyclonal antibody at 1 ug/mL in (A) the presence and (B) absence of blocking peptide. -
Gene Info — IRF8
Entrez GeneID
3394Protein Accession#
NP_002154Gene Name
IRF8
Gene Alias
H-ICSBP, ICSBP, ICSBP1, IRF-8
Gene Description
interferon regulatory factor 8
Omim ID
601565Gene Ontology
HyperlinkGene Summary
Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq
Other Designations
interferon consensus sequence binding protein 1
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Interactome
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Disease
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Publication Reference
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Induction and regulation of IFNs during viral infections.
Malmgaard L.
Journal of Interferon & Cytokine Research 2004 Aug; 24(8):439.
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Toll-like receptor 9 signaling activates NF-kappaB through IFN regulatory factor-8/IFN consensus sequence binding protein in dendritic cells.
Tsujimura H, Tamura T, Kong HJ, Nishiyama A, Ishii KJ, Klinman DM, Ozato K.
Journal of Immunology 2004 Jun; 172(11):6820.
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Interferon consensus sequence-binding protein, a member of the interferon regulatory factor family, suppresses interferon-induced gene transcription.
Nelson N, Marks MS, Driggers PH, Ozato K.
Molecular and Cellular Biology 1993 Jan; 13(1):588.
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Induction and regulation of IFNs during viral infections.
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