BTK polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BTK.
Immunogen
A synthetic peptide corresponding to N-terminus 16 amino acids of human BTK.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Cell lysate)
Western blot analysis of BTK in U-937 cell lysate with BTK polyclonal antibody (Cat # PAB12936) at (A) 0.5, (B) 1, and (C) 2 ug/mL .Immunocytochemistry
Immunocytochemistry of BTK in Daudi cells with BTK polyclonal antibody (Cat # PAB12936) at 10 ug/mL . -
Gene Info — BTK
Entrez GeneID
695Protein Accession#
Q06187Gene Name
BTK
Gene Alias
AGMX1, AT, ATK, BPK, IMD1, MGC126261, MGC126262, PSCTK1, XLA
Gene Description
Bruton agammaglobulinemia tyrosine kinase
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. [provided by RefSeq
Other Designations
B-cell progenitor kinase|Bruton tyrosine kinase|OTTHUMP00000023676|OTTHUMP00000063593|agammaglobulinemia tyrosine kinase|dominant-negative kinase-deficient Brutons tyrosine kinase|tyrosine-protein kinase BTK
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Toll-like receptor signalling.
Akira S, Takeda K.
Nature Reviews. Immunology 2004 Jul; 4(7):499.
-
Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4.
Jefferies CA, Doyle S, Brunner C, Dunne A, Brint E, Wietek C, Walch E, Wirth T, O'Neill LA.
The Journal of Biological Chemistry 2003 Jul; 278(28):26258.
Application:IP, WB-Tr, Human, HEK 293, THP-1 cells.
-
Functions of Bruton's tyrosine kinase in mast and B cells.
Kawakami Y, Kitaura J, Hata D, Yao L, Kawakami T.
Journal of Leukocyte Biology 1999 Mar; 65(3):286.
Application:WB-Ce, WB-Tr, Human, B cells, Mammalian cells, Mast cells.
-
Toll-like receptor signalling.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com