BAK1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BAK1.
Immunogen
A synthetic peptide corresponding to N-terminus 13 amino acids of human BAK1.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of BAK1 in L1210 cell lysates with BAK1 polyclonal antibody (Cat # PAB12926) at (A) 1 and (B) 2 ug/mL .Immunocytochemistry
Immunocytochemistry of BAK1 in L1210 cells with BAK1 polyclonal antibody (Cat # PAB12926) at 2 ug/mL . -
Gene Info — BAK1
Entrez GeneID
578Protein Accession#
Q16611Gene Name
BAK1
Gene Alias
BAK, BAK-LIKE, BCL2L7, CDN1, MGC117255, MGC3887
Gene Description
BCL2-antagonist/killer 1
Omim ID
600516Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq
Other Designations
BCL2-like 7 protein|Bcl-2 homologous antagonist/killer|OTTHUMP00000016211|OTTHUMP00000039620|apoptosis regulator BAK|pro-apoptotic protein BAK
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Interactome
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Disease
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Publication Reference
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Ovatodiolide sensitizes aggressive breast cancer cells to doxorubicin, eliminates their cancer stem cell-like phenotype, and reduces doxorubicin-associated toxicity.
Bamodu OA, Huang WC, Tzeng DT, Wu A, Wang LS, Yeh CT, Chao TY.
Cancer Letters 2015 Aug; 364(2):125.
Application:WB, Human, HS578T, MDA-MB-231 cells.
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The Bcl-2 protein family and its role in the development of neoplastic disease.
Heiser D, Labi V, Erlacher M, Villunger A.
Experimental Gerontology 2004 Aug; 39(8):1125.
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The Bcl-2 family: roles in cell survival and oncogenesis.
Cory S, Huang DC, Adams JM.
Oncogene 2003 Nov; 22(53):8590.
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Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak.
Kiefer MC, Brauer MJ, Powers VC, Wu JJ, Umansky SR, Tomei LD, Barr PJ.
Nature 1995 Apr; 374(6524):736.
Application:Flow Cyt, Human, FL5.12, WI-L2 cells.
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Ovatodiolide sensitizes aggressive breast cancer cells to doxorubicin, eliminates their cancer stem cell-like phenotype, and reduces doxorubicin-associated toxicity.
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