NAIP polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NAIP.
Immunogen
A synthetic peptide corresponding to C-terminus 13 amino acids of human NAIP.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of NAIP in PC-3 cell lysate with NAIP polyclonal antibody (Cat # PAB12920) at (A) 0.5, (B) 1, and (C) 2 ug/mL .Immunocytochemistry
Immunocytochemistry of NAIP in A-549 cells with NAIP polyclonal antibody (Cat # PAB12920) at 10 ug/mL . -
Gene Info — NAIP
Entrez GeneID
4671Protein Accession#
AAC52047Gene Name
NAIP
Gene Alias
BIRC1, FLJ18088, FLJ42520, FLJ58811, NLRB1, psiNAIP
Gene Description
NLR family, apoptosis inhibitory protein
Omim ID
600355Gene Ontology
HyperlinkGene Summary
This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq
Other Designations
NLR family, BIR domain containing 1|OTTHUMP00000125255|baculoviral IAP repeat-containing 1|neuronal apoptosis inhibitory protein|nucleotide-binding oligomerization domain, leucine rich repeat and BIR domain containing 1|psi neuronal apoptosis inhibitory p
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Interactome
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Disease
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Publication Reference
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Neuronal apoptosis-inhibitory protein does not interact with Smac and requires ATP to bind caspase-9.
Davoodi J, Lin L, Kelly J, Liston P, MacKenzie AE.
The Journal of Biological Chemistry 2004 Sep; 279(39):40622.
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The inhibitors of apoptosis: there is more to life than Bcl2.
Liston P, Fong WG, Korneluk RG.
Oncogene 2003 Nov; 22(53):8568.
Application:WB-Tr, Human, Mammalian cells.
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The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy.
Roy N, Mahadevan MS, McLean M, Shutler G, Yaraghi Z, Farahani R, Baird S, Besner-Johnston A, Lefebvre C, Kang X, et al..
Cell 1995 Jan; 80(1):167.
Application:WB-Ti, Human, Human tissues, Livers, Placenta.
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Neuronal apoptosis-inhibitory protein does not interact with Smac and requires ATP to bind caspase-9.
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