TRIM5 gamma polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of TRIM5 gamma expression in human bladder (A) and colon (B) tissue lysate with TRIM5 gamma polyclonal antibody (Cat # PAB12910) at 2 ug /mL .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of TRIM5 gamma in human bladder tissue with TRIM5 gamma polyclonal antibody (Cat # PAB12910) at 2 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TRIM5.
Immunogen
A synthetic peptide corresponding to C-terminus 15 amino acids of human TRIM5 gamma.
Host
Rabbit
Reactivity
Human
Specificity
A band at approximately 35 KDa can be detected.
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of TRIM5 gamma expression in human bladder (A) and colon (B) tissue lysate with TRIM5 gamma polyclonal antibody (Cat # PAB12910) at 2 ug /mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of TRIM5 gamma in human bladder tissue with TRIM5 gamma polyclonal antibody (Cat # PAB12910) at 2 ug/mL . -
Gene Info — TRIM5
Entrez GeneID
85363Protein Accession#
NP_149083Gene Name
TRIM5
Gene Alias
RNF88, TRIM5alpha
Gene Description
tripartite motif-containing 5
Omim ID
608487Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Five alternatively spliced transcript variants for this gene have been described. However, the full length nature of two of the variants has not been determined. [provided by RefSeq
Other Designations
OTTHUMP00000069811|OTTHUMP00000069812|tripartite motif protein TRIM|tripartite motif protein TRIM5|tripartite motif-containing protein 5 alpha
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Interactome
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Disease
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Publication Reference
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Retrovirus resistance factors Ref1 and Lv1 are species-specific variants of TRIM5alpha.
Hatziioannou T, Perez-Caballero D, Yang A, Cowan S, Bieniasz PD.
PNAS 2004 Jul; 101(29):10774.
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The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys.
Stremlau M, Owens CM, Perron MJ, Kiessling M, Autissier P, Sodroski J.
Nature 2004 Feb; 427(6977):848.
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The tripartite motif family identifies cell compartments.
Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A.
The EMBO Journal 2001 May; 20(9):2140.
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Retrovirus resistance factors Ref1 and Lv1 are species-specific variants of TRIM5alpha.
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