CARD11 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of CARD11 expression in mouse thymus tissue lysate with CARD11 polyclonal antibody (Cat # PAB12907) at 0.5 (lane A), 1 (lane B), and 2 ug /mL (lane C), respectively.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of CARD11 in mouse thymus with CARD11 polyclonal antibody (Cat # PAB12907) at 10 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CARD11.
Immunogen
A synthetic peptide corresponding to C-terminus of human CARD11.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
A band at approximately 125 KDa can be detected.
Form
Liquid
Recommend Usage
Western Blot (0.5-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of CARD11 expression in mouse thymus tissue lysate with CARD11 polyclonal antibody (Cat # PAB12907) at 0.5 (lane A), 1 (lane B), and 2 ug /mL (lane C), respectively.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of CARD11 in mouse thymus with CARD11 polyclonal antibody (Cat # PAB12907) at 10 ug/mL . -
Gene Info — CARD11
Entrez GeneID
84433Protein Accession#
Q9BXL7Gene Name
CARD11
Gene Alias
BIMP3, CARMA1, MGC133069
Gene Description
caspase recruitment domain family, member 11
Omim ID
607210Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq
Other Designations
OTTHUMP00000024641|bcl10-interacting maguk protein 3|card-maguk protein 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation.
Gaide O, Martinon F, Micheau O, Bonnet D, Thome M, Tschopp J.
FEBS Letters 2001 May; 496(2-3):121.
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CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B.
Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES.
The Journal of Biological Chemistry 2001 Apr; 276(15):11877.
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Protein modules as organizers of membrane structure.
Fanning AS, Anderson JM.
Current Opinion in Cell Biology 1999 Aug; 11(4):432.
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Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation.
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