CARD8 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of CARD8 expression in K-562 cell lysate with CARD8 polyclonal antibody (Cat # PAB12906) at (A) 2 and (B) 4 ug /mL .
Immunocytochemistry
Immunocytochemistry of CARD8 in K-562 cells with CARD8 polyclonal antibody (Cat # PAB12906) at 10 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CARD8.
Immunogen
A synthetic peptide corresponding to C-terminus of human CARD8.
Host
Rabbit
Reactivity
Human
Specificity
An approximate 45 KDa can be detected.
Form
Liquid
Recommend Usage
Western Blot (2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of CARD8 expression in K-562 cell lysate with CARD8 polyclonal antibody (Cat # PAB12906) at (A) 2 and (B) 4 ug /mL .Immunocytochemistry
Immunocytochemistry of CARD8 in K-562 cells with CARD8 polyclonal antibody (Cat # PAB12906) at 10 ug/mL . -
Gene Info — CARD8
Entrez GeneID
22900Protein Accession#
AAG50014Gene Name
CARD8
Gene Alias
CARDINAL, DACAR, DKFZp779L0366, Dakar, FLJ18119, FLJ18121, KIAA0955, MGC57162, NDPP, NDPP1, TUCAN
Gene Description
caspase recruitment domain family, member 8
Omim ID
609051Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined. [provided by RefSeq
Other Designations
CARD inhibitor of NF-kappaB-activating ligands|CARD8 isoform T47|CARD8 isoform T51|CARD8 isoform T60|apoptotic protein NDPP1|tumor up-regulated CARD-containing antagonist of caspase nine
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Interactome
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Disease
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Publication Reference
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CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis.
Razmara M, Srinivasula SM, Wang L, Poyet JL, Geddes BJ, DiStefano PS, Bertin J, Alnemri ES.
The Journal of Biological Chemistry 2002 Apr; 277(16):13952.
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TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer.
Pathan N, Marusawa H, Krajewska M, Matsuzawa S, Kim H, Okada K, Torii S, Kitada S, Krajewski S, Welsh K, Pio F, Godzik A, Reed JC.
J Biol Chem 2001 Jun; 276(34):32220.
Application：IHC-P, WB-Ce, WB-Tr, Human, HEK293T, MCF7, Jurkat T cells, Colorectal carcinoma.
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DRAL is a p53-responsive gene whose four and a half LIM domain protein product induces apoptosis.
Scholl FA, McLoughlin P, Ehler E, de Giovanni C, Schafer BW.
The Journal of Cell Biology 2000 Oct; 151(3):495.
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CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis.
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