TRAF6 polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of TRAF6 in PC-3 cell lysates with TRAF6 polyclonal antibody (Cat # PAB12896) at 1 ug/mL in the presence (A) or absence (B) of 1 ug blocking peptide.
Immunocytochemistry
Immunocytochemistry of TRAF6 in K-562 cells with TRAF6 polyclonal antibody (Cat # PAB12896) at 0.5 ug/mL .
-
Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TRAF6.
Immunogen
A synthetic peptide corresponding to C-terminus 14 amino acids of human TRAF6.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Cell lysate)
Western blot analysis of TRAF6 in PC-3 cell lysates with TRAF6 polyclonal antibody (Cat # PAB12896) at 1 ug/mL in the presence (A) or absence (B) of 1 ug blocking peptide.Immunocytochemistry
Immunocytochemistry of TRAF6 in K-562 cells with TRAF6 polyclonal antibody (Cat # PAB12896) at 0.5 ug/mL . -
Gene Info — TRAF6
Entrez GeneID
7189Protein Accession#
NP_004611Gene Name
TRAF6
Gene Alias
MGC:3310, RNF85
Gene Description
TNF receptor-associated factor 6
Omim ID
602355Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported. [provided by RefSeq
Other Designations
-
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Analogies between Drosophila and mammalian TRAF pathways.
Wajant H, Scheurich P.
Progress in Molecular and Subcellular Biology 2004 Jan; 34:47.
Application：WB, Human, Mammalian cells.
-
TRAF6 is a critical factor for dendritic cell maturation and development.
Kobayashi T, Walsh PT, Walsh MC, Speirs KM, Chiffoleau E, King CG, Hancock WW, Caamano JH, Hunter CA, Scott P, Turka LA, Choi Y.
Immunity 2003 Sep; 19(3):353.
-
Toll-like receptors.
Takeda K, Kaisho T, Akira S.
Annual Review of Immunology 2001 Dec; 21:335.
-
Analogies between Drosophila and mammalian TRAF pathways.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com