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Last updated: 2017/6/18
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TRAF6 polyclonal antibody

  • Catalog # : PAB12896
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of TRAF6.
  • Immunogen:
  • A synthetic peptide corresponding to C-terminus 14 amino acids of human TRAF6.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse, Rat
  • Form:
  • Liquid
  • Recommend Usage:
  • Western Blot (1-2 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.02% sodium azide)
  • Storage Instruction:
  • Store at 4°C for three months. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • 3.
  • Toll-like receptors.
    Takeda K, Kaisho T, Akira S.Annu Rev Immunol. 2003;21:335-76. Epub 2001 Dec 19.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of TRAF6 in PC-3 cell lysates with TRAF6 polyclonal antibody (Cat # PAB12896) at 1 ug/mL in the presence (A) or absence (B) of 1 ug blocking peptide.
  • Immunocytochemistry
  • Immunocytochemistry
  • Immunocytochemistry of TRAF6 in K-562 cells with TRAF6 polyclonal antibody (Cat # PAB12896) at 0.5 ug/mL .
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 7189
  • Gene Name:
  • TRAF6
  • Gene Alias:
  • MGC:3310,RNF85
  • Gene Description:
  • TNF receptor-associated factor 6
  • Gene Summary:
  • The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported. [provided by RefSeq
  • Other Designations:
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