PAK7 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of PAK7 in T24 lysate with PAK7 polyclonal antibody (Cat # PAB12891) at 2 and 4 ug/mL .
Immunocytochemistry
Immunocytochemistry of PAK7 in K-562 cells with PAK7 polyclonal antibody (Cat # PAB12891) at 2 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PAK7.
Immunogen
A synthetic peptide corresponding to internal region 13 amino acids of human PAK7.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (2-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of PAK7 in T24 lysate with PAK7 polyclonal antibody (Cat # PAB12891) at 2 and 4 ug/mL .Immunocytochemistry
Immunocytochemistry of PAK7 in K-562 cells with PAK7 polyclonal antibody (Cat # PAB12891) at 2 ug/mL . -
Gene Info — PAK7
Entrez GeneID
57144Protein Accession#
Q9P286Gene Name
PAK7
Gene Alias
KIAA1264, MGC26232, PAK5
Gene Description
p21 protein (Cdc42/Rac)-activated kinase 7
Omim ID
608038Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq
Other Designations
OTTHUMP00000030258|OTTHUMP00000030259|OTTHUMP00000030260|p21(CDKN1A)-activated kinase 7|p21-activated kinase 7|protein kinase PAK5|serine/threonine-protein kinase PAK7
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Interactome
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Pathway
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Disease
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Publication Reference
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p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD.
Cotteret S, Jaffer ZM, Beeser A, Chernoff J.
Molecular and Cellular Biology 2003 Aug; 23(16):5526.
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p21-activated kinases: three more join the Pak.
Jaffer ZM, Chernoff J.
The International Journal of Biochemistry & Cell Biology 2002 Jul; 34(7):713.
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PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells.
Dan C, Nath N, Liberto M, Minden A.
Molecular and Cellular Biology 2002 Jan; 22(2):567.
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p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD.
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