AATF polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of AATF in human small intestine tissue lysate with AATF polyclonal antibody (Cat # PAB12886) at 0.5, 1 and 2 ug/mL .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of AATF in human small intestine tissue with AATF polyclonal antibody (Cat # PAB12886) at 10 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of AATF.
Immunogen
A synthetic peptide corresponding to C-terminus of human AATF.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
AATF antibody is human and mouse reactive.
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of AATF in human small intestine tissue lysate with AATF polyclonal antibody (Cat # PAB12886) at 0.5, 1 and 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of AATF in human small intestine tissue with AATF polyclonal antibody (Cat # PAB12886) at 10 ug/mL . -
Gene Info — AATF
Entrez GeneID
26574Protein Accession#
NP_036270Gene Name
AATF
Gene Alias
CHE-1, CHE1, DED
Gene Description
apoptosis antagonizing transcription factor
Omim ID
608463Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq
Other Designations
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Interactome
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Disease
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Publication Reference
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Identification of novel transcription factor-like gene from human intestinal cells.
Lindfors K, Halttunen T, Huotari P, Nupponen N, Vihinen M, Visakorpi T, Maki M, Kainulainen H.
Biochemical and Biophysical Research Communications 2000 Sep; 276(2):660.
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AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis.
Page G, Lodige I, Kogel D, Scheidtmann KH.
FEBS Letters 1999 Nov; 462(1-2):187.
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ZIP kinase, a novel serine/threonine kinase which mediates apoptosis.
Kawai T, Matsumoto M, Takeda K, Sanjo H, Akira S.
Molecular and Cellular Biology 1998 Mar; 18(3):1642.
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Identification of novel transcription factor-like gene from human intestinal cells.
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