ENDOG polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of ENDOG in mouse (M) NIH/3T3 and human (H) HepG2 cell lysates with ENDOG polyclonal antibody (Cat # PAB12884) at 2 ug/mL .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of ENDOG in human pancreas with ENDOG polyclonal antibody (Cat # PAB12884) at 15 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ENDOG.
Immunogen
A synthetic peptide corresponding to N-terminus 15 amino acids of human ENDOG.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
A 35 KDa band can be detected. It is human, mouse and rat reactive.
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for up to one year.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of ENDOG in mouse (M) NIH/3T3 and human (H) HepG2 cell lysates with ENDOG polyclonal antibody (Cat # PAB12884) at 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of ENDOG in human pancreas with ENDOG polyclonal antibody (Cat # PAB12884) at 15 ug/mL . -
Gene Info — ENDOG
Entrez GeneID
2021Protein Accession#
NP_004426Gene Name
ENDOG
Gene Alias
FLJ27463
Gene Description
endonuclease G
Omim ID
600440Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. [provided by RefSeq
Other Designations
OTTHUMP00000022301
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Interactome
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Pathway
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Publication Reference
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Apoptosis. DNA destroyers.
Hengartner MO.
Nature 2001 Jul; 412(6842):27.
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Mitochondrial endonuclease G is important for apoptosis in C. elegans.
Parrish J, Li L, Klotz K, Ledwich D, Wang X, Xue D.
Nature 2001 Jul; 412(6842):90.
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Endonuclease G is an apoptotic DNase when released from mitochondria.
Li LY, Luo X, Wang X.
Nature 2001 Jul; 412(6842):95.
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Apoptosis. DNA destroyers.
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