NLRP2 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of NARP2 in PC-3 cell lysate with NLRP2 polyclonal antibody (Cat # PAB12883) at 1 and 2 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NLRP2.
Immunogen
A synthetic peptide corresponding to C-terminus 12 amino acids of human NLRP2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of NARP2 in PC-3 cell lysate with NLRP2 polyclonal antibody (Cat # PAB12883) at 1 and 2 ug/mL . -
Gene Info — NLRP2
Entrez GeneID
55655Protein Accession#
NP_060322Gene Name
NLRP2
Gene Alias
CLR19.9, FLJ20510, NALP2, NBS1, PAN1, PYPAF2
Gene Description
NLR family, pyrin domain containing 2
Omim ID
609364Gene Ontology
HyperlinkGene Summary
NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors (see TLR4; MIM 603030). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM
Other Designations
NACHT, LRR and PYD containing protein 2|NACHT, leucine rich repeat and PYD containing 2|PYRIN-Containing APAF1-like|nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 2
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Interactome
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Disease
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Publication Reference
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NLRs join TLRs as innate sensors of pathogens.
Martinon F, Tschopp J.
Trends in Immunology 2005 Aug; 26(8):447.
Application：WB, Human, Human mammalian cells.
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PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages.
Bruey JM, Bruey-Sedano N, Newman R, Chandler S, Stehlik C, Reed JC.
The Journal of Biological Chemistry 2004 Sep; 279(50):51897.
Application：WB-Ce, WB-Tr, Human, HEK 293T, MCF-7, THP-1 cells.
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NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.
Agostini L, Martinon F, Burns K, McDermott MF, Hawkins PN, Tschopp J.
Immunity 2004 Mar; 20(3):319.
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NLRs join TLRs as innate sensors of pathogens.
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