PCBP4 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of PCBP4 in HeLa cell lysate with PCBP4 polyclonal antibody (Cat # PAB12868) at 0.5, 1 and 2 ug/mL .
Immunocytochemistry
Immunocytochemistry of PCBP4 in HeLa cells with PCBP4 polyclonal antibody (Cat # PAB12868) at 1 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PCBP4.
Immunogen
A synthetic peptide corresponding to C-terminus 17 amino acids of human PCBP4.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of PCBP4 in HeLa cell lysate with PCBP4 polyclonal antibody (Cat # PAB12868) at 0.5, 1 and 2 ug/mL .Immunocytochemistry
Immunocytochemistry of PCBP4 in HeLa cells with PCBP4 polyclonal antibody (Cat # PAB12868) at 1 ug/mL . -
Gene Info — PCBP4
Entrez GeneID
57060Protein Accession#
EAW65166Gene Name
PCBP4
Gene Alias
LIP4, MCG10
Gene Description
poly(rC) binding protein 4
Omim ID
608503Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined. [provided by RefSeq
Other Designations
LYST-interacting protein|RNA binding protein MCG10|alphaCP-4 protein
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Interactome
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Disease
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Publication Reference
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Alpha CP-4, encoded by a putative tumor suppressor gene at 3p21, but not its alternative splice variant alpha CP-4a, is underexpressed in lung cancer.
Pio R, Zudaire I, Pino I, Castano Z, Zabalegui N, Vicent S, Garcia-Amigot F, Odero MD, Lozano MD, Garcia-Foncillas J, Calasanz MJ, Montuenga LM.
Cancer Research 2004 Jun; 64(12):4171.
Application：IHC-P, Human, Human lung cancer.
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The poly(C)-binding proteins: a multiplicity of functions and a search for mechanisms.
Makeyev AV, Liebhaber SA.
RNA 2002 Mar; 8(3):265.
Application：IHC, WB-Tr, Human, Mouse, Mammalian cells, Tissues.
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MCG10, a novel p53 target gene that encodes a KH domain RNA-binding protein, is capable of inducing apoptosis and cell cycle arrest in G(2)-M.
Zhu J, Chen X.
Molecular and Cellular Biology 2000 Aug; 20(15):5602.
Application：WB, Human, HCT-116, LS174T, MCF-7 cells.
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Alpha CP-4, encoded by a putative tumor suppressor gene at 3p21, but not its alternative splice variant alpha CP-4a, is underexpressed in lung cancer.
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