RRM2B polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of RRM2B.
Immunogen
A synthetic peptide corresponding to amino acids 2-17 of human RRM2B.
Sequence
GDPERPEAAGLDQDER
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
A 39 KDa band can be detected.
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of RRM2B expression in A-431 cell lysate with RRM2B polyclonal antibody (Cat # PAB12860) at 0.5 and 1 ug /mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of RRM2B in human lung tissue with RRM2B polyclonal antibody (Cat # PAB12860) at 1 ug/mL . -
Gene Info — RRM2B
Entrez GeneID
50484Protein Accession#
BAA92434Gene Name
RRM2B
Gene Alias
DKFZp686M05248, MGC102856, MGC42116, p53R2
Gene Description
ribonucleotide reductase M2 B (TP53 inducible)
Omim ID
604712Gene Ontology
HyperlinkOther Designations
p53-inducible ribonucleotide reductase small subunit 2 homolog|p53-inducible ribonucleotide reductase small subunit 2 long form|p53-inducible ribonucleotide reductase small subunit 2 short form gamma
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Interactome
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Pathway
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Disease
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Publication Reference
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Rrm2b deletion causes mitochondrial metabolic defects in renal tubules.
Chen YF, Lin IH, Guo YR, Chiu WJ, Wu MS, Jia W, Yen Y.
Scientific Reports 2019 Sep; 9(1):13238.
Application:IHC-P, Mouse, Kidney.
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p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53.
Oda K, Arakawa H, Tanaka T, Matsuda K, Tanikawa C, Mori T, Nishimori H, Tamai K, Tokino T, Nakamura Y, Taya Y.
Cell 2000 Sep; 102(6):849.
Application:WB, Human, MCF-7, NCI-H1299 cells.
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Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis.
Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N.
Science 2000 May; 288(5468):1053.
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Linkage of ATM to cell cycle regulation by the Chk2 protein kinase.
Matsuoka S, Huang M, Elledge SJ.
Science 1998 Dec; 282(5395):1893.
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Rrm2b deletion causes mitochondrial metabolic defects in renal tubules.
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