IKBKAP polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of IKBKAP.
Immunogen
A synthetic peptide corresponding to C-terminus 16 amino acids of human IKBKAP.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of IKBKAP in A-20 cell lysate with IKBKAP polyclonal antibody (Cat # PAB12857) at in 0.5, and 1 ug/mL .Immunocytochemistry
Immunocytochemistry of IKBKAP in A-20 cells with IKBKAP polyclonal antibody (Cat # PAB12857) at 1 ug/mL . -
Gene Info — IKBKAP
Entrez GeneID
8518Protein Accession#
AAC64258Gene Name
IKBKAP
Gene Alias
DKFZp781H1425, DYS, ELP1, FD, FLJ12497, IKAP, IKI3, TOT1
Gene Description
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a scaffold protein and a regulator for 3 different kinases involved in proinflammatory signaling. This encoded protein can bind NF-kappa-B-inducing kinase (NIK) and IKKs through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia. [provided by RefSeq
Other Designations
OTTHUMP00000021869|OTTHUMP00000063889
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Interactome
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Disease
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Publication Reference
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Elongator regulates the melanocortin satiety pathway.
Joseph Walters, Cody Walters, BreAnna Cameron, Lynn George.
Biochemical and Biophysical Research Communications 2022 Jul; 613:73.
Application:WB-Tr, Mouse, Mouse pituiary.
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Loss of Elp1 perturbs histone H2A.Z and the Notch signaling pathway.
BreAnna Cameron, Elin Lehrmann, Tien Chih, Joseph Walters, Richard Buksch, Sara Snyder, Joy Goffena, Frances Lefcort, Kevin G Becker, Lynn George.
Biology Open 2021 Sep; 10(9):bio058979.
Application:WB, Mouse, Mouse Brain.
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Purification and characterization of the human elongator complex.
Hawkes NA, Otero G, Winkler GS, Marshall N, Dahmus ME, Krappmann D, Scheidereit C, Thomas CL, Schiavo G, Erdjument-Bromage H, Tempst P, Svejstrup JQ.
J Biol Chem 2001 Nov; 277(4):3047.
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Familial dysautonomia is caused by mutations of the IKAP gene.
Anderson SL, Coli R, Daly IW, Kichula EA, Rork MJ, Volpi SA, Ekstein J, Rubin BY.
American Journal of Human Genetics 2001 Mar; 68(3):753.
Application:WB-Ce, WB-Tr, Human, DY491, GM05106 cells.
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IKAP is a scaffold protein of the IkappaB kinase complex.
Cohen L, Henzel WJ, Baeuerle PA.
Nature 1998 Sep; 395(6699):292.
Application:IP, WB-Tr, Human, 293/IL-I- receptor cells.
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Elongator regulates the melanocortin satiety pathway.
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