NPHS1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NPHS1.
Immunogen
A synthetic peptide corresponding to C-terminus 14 amino acids of human NPHS1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for up to one year.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of NPHS1 in mouse kidney tissue lysate with NPHS1 polyclonal antibody (Cat # PAB12848) at 1 ug/mL in the (A) absence and (B) presence of blocking peptide.Immunohistochemistry
Immunohistochemical staining of mouse kidney tissue with 1 ug/mL NPHS1 polyclonal antibody (Cat # PAB12848). -
Gene Info — NPHS1
Entrez GeneID
4868Protein Accession#
NP_004637Gene Name
NPHS1
Gene Alias
CNF, NPHN
Gene Description
nephrosis 1, congenital, Finnish type (nephrin)
Gene Ontology
HyperlinkGene Summary
Nephrin is a kidney glomerular filtration barrier protein that is an essential component of the interpodocyte-spanning slit diaphragm. Mutations in the nephrin gene are associated with congenital nephrotic syndrome (NPHS1; MIM 256300).[supplied by OMIM
Other Designations
nephrin|renal glomerulus-specific cell adhesion receptor
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Interactome
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Disease
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Publication Reference
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Molecular basis of glomerular permselectivity.
Tryggvason K, Wartiovaara J.
Current Opinion in Nephrology and Hypertension 2001 Jul; 10(4):543.
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Unraveling the mechanisms of glomerular ultrafiltration: nephrin, a key component of the slit diaphragm.
Tryggvason K.
Journal of the American Society of Nephrology 1999 Nov; 10(11):2440.
Application:IEM, IF, Human, Human kidney.
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Positionally cloned gene for a novel glomerular protein--nephrin--is mutated in congenital nephrotic syndrome.
Kestila M, Lenkkeri U, Mannikko M, Lamerdin J, McCready P, Putaala H, Ruotsalainen V, Morita T, Nissinen M, Herva R, Kashtan CE, Peltonen L, Holmberg C, Olsen A, Tryggvason K.
Molecular Cell 1998 Mar; 1(4):575.
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Molecular basis of glomerular permselectivity.
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