SNW1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of SNW1 in mouse skeletal muscle tissue lysate with SNW1 polyclonal antibody (Cat # PAB12847) at 0.5 and 1 ug/mL .
Immunofluorescence
Immunofluorescence of SNW1 in human kidney tissue with SNW1 polyclonal antibody (Cat # PAB12847) at 20 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SNW1.
Immunogen
A synthetic peptide corresponding to C-terminus 16 amino acids of human SNW1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of SNW1 in mouse skeletal muscle tissue lysate with SNW1 polyclonal antibody (Cat # PAB12847) at 0.5 and 1 ug/mL .Immunofluorescence
Immunofluorescence of SNW1 in human kidney tissue with SNW1 polyclonal antibody (Cat # PAB12847) at 20 ug/mL . -
Gene Info — SNW1
Entrez GeneID
22938Protein Accession#
NP_036377Gene Name
SNW1
Gene Alias
Bx42, MGC119379, NCOA-62, PRPF45, Prp45, SKIIP, SKIP
Gene Description
SNW domain containing 1
Omim ID
603055Gene Ontology
HyperlinkGene Summary
This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. [provided by RefSeq
Other Designations
SKI interacting protein|SKI-interacting protein|homolog of Drosophila BX42|nuclear protein SkiP|nuclear receptor coactivator, 62-kD
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Interactome
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Pathway
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Disease
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Publication Reference
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Ski and SnoN: negative regulators of TGF-beta signaling.
Luo K.
Current Opinion in Genetics & Development 2004 Feb; 14(1):65.
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TGF-beta signaling in tumor suppression and cancer progression.
Derynck R, Akhurst RJ, Balmain A.
Nat Genet 2001 Oct; 29(2):117.
Application：IHC, WB, Human, Cancers, Mammalian cells.
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Unique sequence, ski, in Sloan-Kettering avian retroviruses with properties of a new cell-derived oncogene.
Li Y, Turck CM, Teumer JK, Stavnezer E.
Journal of Virology 1986 Mar; 57(3):1065.
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Ski and SnoN: negative regulators of TGF-beta signaling.
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