DAXX polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of DAXX in HeLa total cell lysate with DAXX polyclonal antibody (Cat # PAB12829) at 1 mg/ml.
Immunocytochemistry
Immunocytochemistry of DAXX in HeLa cells with DAXX polyclonal antibody (Cat # PAB12829) at 10 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of DAXX.
Immunogen
A synthetic peptide corresponding to C-terminus of human DAXX.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
A 120 KDa major band can be detected.
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of DAXX in HeLa total cell lysate with DAXX polyclonal antibody (Cat # PAB12829) at 1 mg/ml.Immunocytochemistry
Immunocytochemistry of DAXX in HeLa cells with DAXX polyclonal antibody (Cat # PAB12829) at 10 ug/mL . -
Gene Info — DAXX
Entrez GeneID
1616Protein Accession#
CAG33366Gene Name
DAXX
Gene Alias
BING2, DAP6, EAP1, MGC126245, MGC126246
Gene Description
death-domain associated protein
Omim ID
603186Gene Ontology
HyperlinkGene Summary
This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
CENP-C binding protein|ETS1-associated protein 1|Fas-binding protein|OTTHUMP00000029289|OTTHUMP00000029290|death-associated protein 6
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Interactome
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Pathway
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Disease
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Publication Reference
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Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region.
Kiriakidou M, Driscoll DA, Lopez-Guisa JM, Strauss JF 3rd.
DNA and Cell Biology 1997 Nov; 16(11):1289.
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Daxx, a novel Fas-binding protein that activates JNK and apoptosis.
Yang X, Khosravi-Far R, Chang HY, Baltimore D.
Cell 1997 Jun; 89(7):1067.
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Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region.
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