TNFSF10 polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Western Blot (Transfected lysate)
Western blot analysis of TRAIL in HeLa cell lysate containing 10, 2.5, or 1 ng of recombinant protein containing extracellular domain of TNSF10 with TNFSF10 polyclonal antibody (Cat # PAB12822) at 1 ug/mL.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of TNFSF10 in human brain tissue with TNFSF10 polyclonal antibody (Cat # PAB12822) at 20 ug/mL .
-
Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TNFSF10.
Immunogen
A synthetic peptide corresponding to C-terminus of human TNFSF10.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Transfected lysate)
Western blot analysis of TRAIL in HeLa cell lysate containing 10, 2.5, or 1 ng of recombinant protein containing extracellular domain of TNSF10 with TNFSF10 polyclonal antibody (Cat # PAB12822) at 1 ug/mL.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of TNFSF10 in human brain tissue with TNFSF10 polyclonal antibody (Cat # PAB12822) at 20 ug/mL . -
Gene Info — TNFSF10
Entrez GeneID
8743Protein Accession#
NP_003801Gene Name
TNFSF10
Gene Alias
APO2L, Apo-2L, CD253, TL2, TRAIL
Gene Description
tumor necrosis factor (ligand) superfamily, member 10
Omim ID
603598Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. [provided by RefSeq
Other Designations
Apo-2 ligand|TNF-related apoptosis inducing ligand TRAIL|tumor necrosis factor (ligand) family, member 10|tumor necrosis factor apoptosis-inducing ligand splice variant delta
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB.
Schneider P, Thome M, Burns K, Bodmer JL, Hofmann K, Kataoka T, Holler N, Tschopp J.
Immunity 1997 Dec; 7(6):831.
-
The receptor for the cytotoxic ligand TRAIL.
Pan G, O'Rourke K, Chinnaiyan AM, Gentz R, Ebner R, Ni J, Dixit VM.
Science 1997 Apr; 276(5309):111.
-
Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family.
Pitti RM, Marsters SA, Ruppert S, Donahue CJ, Moore A, Ashkenazi A.
The Journal of Biological Chemistry 1996 May; 271(22):12687.
-
TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com