PON1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of PON1.
Immunogen
A synthetic peptide corresponding to amino acids at internal region of human PON1.
Sequence
C-EEPKVTQVYAEN
Host
Goat
Theoretical MW (kDa)
39.7
Reactivity
Human
Specificity
37 KDa band observed in human Liver lysates (calculated MW of 39.7 KDa according to NP_000437.3).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:2000)
Western blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
PON1 polyclonal antibody (Cat # PAB12817) (1 ug/mL) staining of human liver lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PON1
Entrez GeneID
5444Protein Accession#
NP_000437.3Gene Name
PON1
Gene Alias
ESA, PON
Gene Description
paraoxonase 1
Omim ID
168820Gene Ontology
HyperlinkGene Summary
The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3. [provided by RefSeq
Other Designations
arylesterase B-type|esterase A|paraoxonase B-type|serum aryldiakylphosphatase
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Interactome
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Pathway
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Disease
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Publication Reference
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Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk.
Bhattacharyya T, Nicholls SJ, Topol EJ, Zhang R, Yang X, Schmitt D, Fu X, Shao M, Brennan DM, Ellis SG, Brennan ML, Allayee H, Lusis AJ, Hazen SL.
JAMA 2008 Mar; 299(11):1265.
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Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk.
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