Goat polyclonal antibody raised against synthetic peptide of GRM7.
A synthetic peptide corresponding to amino acids at internal region of human GRM7.
Theoretical MW (kDa):
This antibody is expected to recognize both reported isoforms (NP_000835.1; NP_870989.1). 100 KDa band observed in human Brain (Cerebellum) and in Mouse and Rat Brain lysates (calculated MW of 102 KDa according to NP_000835.1).
Antigen affinity purification
ELISA (1:32000) Western blot (0.5-2 ug/mL) The optimal working dilution should be determined by the end user.
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Store at -20°C. Aliquot to avoid repeated freezing and thawing.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq