GRM7 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
GRM7 polyclonal antibody (Cat # PAB12813) (0.5 ug/mL) staining of human cerebellum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of GRM7.
Immunogen
A synthetic peptide corresponding to amino acids at internal region of human GRM7.
Sequence
NCKLTISGSKKEDT
Host
Goat
Theoretical MW (kDa)
102, 103
Reactivity
Human
Specificity
This antibody is expected to recognize both reported isoforms (NP_000835.1; NP_870989.1). 100 KDa band observed in human Brain (Cerebellum) and in Mouse and Rat Brain lysates (calculated MW of 102 KDa according to NP_000835.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:32000)
Western blot (0.5-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
GRM7 polyclonal antibody (Cat # PAB12813) (0.5 ug/mL) staining of human cerebellum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — GRM7
Entrez GeneID
2917Protein Accession#
NP_000835.1;NP_870989.1Gene Name
GRM7
Gene Alias
FLJ40498, GLUR7, GPRC1G, MGLUR7, mGlu7
Gene Description
glutamate receptor, metabotropic 7
Omim ID
604101Gene Ontology
HyperlinkGene Summary
L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
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Interactome
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Pathway
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Disease
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Publication Reference
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Glutamate receptor metabotropic 7 is cis-regulated in the mouse brain and modulates alcohol drinking.
Vadasz C, Saito M, Gyetvai BM, Oros M, Szakall I, Kovacs KM, Prasad VV, Toth R.
Genomics 2007 Dec; 90(6):690.
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Glutamate receptor metabotropic 7 is cis-regulated in the mouse brain and modulates alcohol drinking.
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