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Last updated: 2016/12/4
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GRN polyclonal antibody

  • Catalog # : PAB12812
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  • Specification
  • Product Description:
  • Goat polyclonal antibody raised against synthetic peptide of GRN.
  • Immunogen:
  • A synthetic peptide corresponding to amino acids at internal region of human GRN.
  • Sequence:
  • QSKCLSKENATTD
  • Host:
  • Goat
  • Theoretical MW (kDa):
  • 63.5
  • Reactivity:
  • Human
  • Specificity:
  • 60 KDa band observed in lysates of A549 and HeLa (calculated MW of 63.5 KDa according to NP_002078.1).
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Concentration:
  • 0.5 mg/mL
  • Recommend Usage:
  • ELISA (1:8000)
    Western blot (1-3 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • GRN polyclonal antibody (Cat # PAB12812) (1 ug/mL) staining of HeLa lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • ELISA
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 2896
  • Gene Name:
  • GRN
  • Gene Alias:
  • GEP,GP88,PCDGF,PEPI,PGRN
  • Gene Description:
  • granulin
  • Gene Summary:
  • Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq
  • Other Designations:
  • PC cell-derived growth factor,acrogranin,granulin-epithelin,proepithelin,progranulin
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