GRN polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
GRN polyclonal antibody (Cat # PAB12812) (1 ug/mL) staining of HeLa lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of GRN.
Immunogen
A synthetic peptide corresponding to amino acids at internal region of human GRN.
Sequence
QSKCLSKENATTD
Host
Goat
Theoretical MW (kDa)
63.5
Reactivity
Human
Specificity
60 KDa band observed in lysates of A549 and HeLa (calculated MW of 63.5 KDa according to NP_002078.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:8000)
Western blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
GRN polyclonal antibody (Cat # PAB12812) (1 ug/mL) staining of HeLa lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — GRN
Entrez GeneID
2896Protein Accession#
NP_002078.1Gene Name
GRN
Gene Alias
GEP, GP88, PCDGF, PEPI, PGRN
Gene Description
granulin
Gene Ontology
HyperlinkGene Summary
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq
Other Designations
PC cell-derived growth factor|acrogranin|granulin-epithelin|proepithelin|progranulin
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Interactome
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Disease
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Publication Reference
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In vivo and postmortem clinicoanatomical correlations in frontotemporal dementia and parkinsonism linked to chromosome 17.
Ghetti B, Spina S, Murrell JR, Huey ED, Pietrini P, Sweeney B, Wassermann EM, Keohane C, Farlow MR, Grafman J.
Neuro-Degenerative Diseases 2008 Mar; 5(3-4):215.
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In vivo and postmortem clinicoanatomical correlations in frontotemporal dementia and parkinsonism linked to chromosome 17.
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