STAT1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
The tissue lysate derived from GH stimulated mouse liver was immunoblotted by STAT1 polyclonal antibody (Cat # PAB12783) at 1 : 500.
Dot Blot (Peptide)
Dot Blo t: 1 ug peptide was blot onto NC membrane.
A : STAT1 (pY701) (Phosphospecific)
B : STAT1 (PairedY701) (Non phosphospeicfic)
were blotted at a 1 : 2000 dilution by :
1 : STAT1 polyclonal antibody (Cat # PAB12783),
2 : Phospho-STAT1 Y701 polyclonal antibody (Cat # PAB12752).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of STAT1.
Immunogen
A synthetic peptide corresponding to residues surrounding Y701 (TGYIK) of human, mouse and rat STAT1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody recognizes STAT1 without a phosphorylated sites of Tyr701. It does not cross-react with phosphospecific peptide.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (0.1-1 ug/mL)
ELISA (0.01-0.1 ug/mL)
Immunoprecipitation (2-5 ug/mL)
Immunohistochemistry (1:50)
The optimal working dilution should be determined by the end user.Storage Buffer
In TBS, pH 7.2 (BSA, 10% Proclin300)
Storage Instruction
Store at 4°C. For long term storage store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Tissue lysate)
The tissue lysate derived from GH stimulated mouse liver was immunoblotted by STAT1 polyclonal antibody (Cat # PAB12783) at 1 : 500.Immunohistochemistry
Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
Dot Blot (Peptide)
Dot Blo t: 1 ug peptide was blot onto NC membrane.
A : STAT1 (pY701) (Phosphospecific)
B : STAT1 (PairedY701) (Non phosphospeicfic)
were blotted at a 1 : 2000 dilution by :
1 : STAT1 polyclonal antibody (Cat # PAB12783),
2 : Phospho-STAT1 Y701 polyclonal antibody (Cat # PAB12752). -
Gene Info — STAT1
Entrez GeneID
6772Gene Name
STAT1
Gene Alias
DKFZp686B04100, ISGF-3, STAT91
Gene Description
signal transducer and activator of transcription 1, 91kDa
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq
Other Designations
OTTHUMP00000165047|signal transducer and activator of transcription 1|signal transducer and activator of transcription-1|transcription factor ISGF-3 components p91/p84
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Gene Info — Stat1
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Gene Info — Stat1
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Interactome
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Pathway
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Disease
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Publication Reference
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SHP-2 is a dual-specificity phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues in nuclei.
Wu TR, Hong YK, Wang XD, Ling MY, Dragoi AM, Chung AS, Campbell AG, Han ZY, Feng GS, Chin YE.
The Journal of Biological Chemistry 2002 Dec; 277(49):47572.
Application：WB-Ce, WB-Tr, Human, Mouse, A-431 cells, HEK 293T cells, MEFs.
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SHP-2 is a dual-specificity phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues in nuclei.
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