SOCS4 polyclonal antibody
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More Files
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Western Blot
The tissue/cell lysates derived from mouse brain (lane 1), HeLa (lane 2) were immuno-probed by SOCS4 polyclonal antibody (Cat # PAB12781) at 1 : 500. An immune-reactive band is observed around ~50 kDa.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SOCS4.
Immunogen
A synthetic peptide corresponding to C-terminus of human, mouse and rat SOCS4.
Host
Rabbit
Theoretical MW (kDa)
50
Reactivity
Human, Mouse
Specificity
This antibody recognizes ~50 KDa of SOCS4.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (0.1-1 ug/mL)
ELISA (0.01-0.1 ug/mL)
Immunoprecipitation (2-5 ug/mL)
Immunohistochemistry (0.5-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In TBS, pH 7.2 (BSA, 10% Proclin300)
Storage Instruction
Store at 4°C. For long term storage store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
The tissue/cell lysates derived from mouse brain (lane 1), HeLa (lane 2) were immuno-probed by SOCS4 polyclonal antibody (Cat # PAB12781) at 1 : 500. An immune-reactive band is observed around ~50 kDa.Immunohistochemistry
Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — Socs4
Entrez GeneID
67296Gene Name
Socs4
Gene Alias
3110032M18Rik, A730004F22Rik, AI427843, AU015727, AU015859, MGC143730, MGC143731, Socs7
Gene Description
suppressor of cytokine signaling 4
Gene Ontology
HyperlinkOther Designations
suppressor of cytokine signaling 7|suppressor of cytokine signalling 4
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Gene Info — SOCS4
Entrez GeneID
122809Gene Name
SOCS4
Gene Alias
DKFZp686J1568, SOCS7
Gene Description
suppressor of cytokine signaling 4
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
SH2 domain containing SOCS box protein|suppressor of cytokine signaling 7
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Gene Info — Socs4
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Interactome
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Pathway
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Disease
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Publication Reference
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Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation.
Bullock AN, Rodriguez MC, Debreczeni JE, Songyang Z, Knapp S.
Structure 2007 Nov; 15(11):1493.
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Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation.
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