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Last updated: 2016/12/4
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SOCS1 polyclonal antibody

  • Catalog # : PAB12778
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of SOCS1.
  • Immunogen:
  • A synthetic peptide corresponding to C-terminus of human and mouse SOCS1.
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 24
  • Reactivity:
  • Human, Mouse
  • Specificity:
  • This antibody recognizes ~24 KDa of SOCS1.
  • Form:
  • Liquid
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • Western Blot (0.1-1 ug/mL)
    ELISA (0.01-0.1 ug/mL)
    Immunoprecipitation (2-5 ug/mL)
    Immunohistochemistry (0.5-2 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In TBS, pH 7.2 (BSA, 10% Proclin300)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C or lower.
    Aliquot to avoid repeated freezing and thawing.
  • Publication Reference
  • Applications
  • Western Blot
  • Western Blot
  • The tissue/cell lysate derived from mouse liver (Lane 1), mouse muscle (Lane 2) and MCF-7 (Lane 3) were immunoprobed by SOCS1 polyclonal antibody (Cat # PAB12778) at 1 : 500. An immunoreactive band is observed around ~24kDa.
  • Immunohistochemistry
  • Immunoprecipitation
  • ELISA
  • Application Image
  • Immunohistochemistry
  • Immunoprecipitation
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 8651
  • Gene Name:
  • SOCS1
  • Gene Alias:
  • CIS1,CISH1,JAB,SOCS-1,SSI-1,SSI1,TIP3
  • Gene Description:
  • suppressor of cytokine signaling 1
  • Gene Summary:
  • This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq
  • Other Designations:
  • JAK binding protein,STAT induced SH3 protein 1,Tec-interacting protein 3,cytokine-inducible SH2 protein 1
  • Gene Information
  • Gene Name:
  • Socs1
  • Gene Alias:
  • Cish1,Cish7,JAB,SOCS-1,SSI-1
  • Gene Description:
  • suppressor of cytokine signaling 1
  • Other Designations:
  • JAK-binding protein,JAK2-binding protein,STAT-induced STAT inhibitor 1,cytokine inducible SH2-containing protein 1,cytokine inducible SH2-containing protein 7
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