JAK2 polyclonal antibody
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More Files
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Immunoprecipitation
The cell lysate (5 mg) derived from HEK 293 transfected by JAK2 was immunoprecipitated by 5 ug of JAK2 polyclonal antibody (Cat # PAB12769) and detected by the same antibody at 1 : 500.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of JAK2.
Immunogen
A synthetic peptide corresponding to C-terminus of human, mouse and rat JAK2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody recognizes JAK2. It does not cross-react with JAK1 or JAK3.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (0.1-1 ug/mL)
ELISA (0.01-0.1 ug/mL)
Immunoprecipitation (2-5 ug/mL)
Immunohistochemistry (1-2.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In TBS, pH 7.2 (BSA, 10% Proclin300)
Storage Instruction
Store at 4°C. For long term storage store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry
Immunoprecipitation
The cell lysate (5 mg) derived from HEK 293 transfected by JAK2 was immunoprecipitated by 5 ug of JAK2 polyclonal antibody (Cat # PAB12769) and detected by the same antibody at 1 : 500.Enzyme-linked Immunoabsorbent Assay
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Gene Info — JAK2
Entrez GeneID
3717Gene Name
JAK2
Gene Alias
JTK10
Gene Description
Janus kinase 2 (a protein tyrosine kinase)
Gene Ontology
HyperlinkGene Summary
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq
Other Designations
Janus kinase 2|OTTHUMP00000021024|OTTHUMP00000043260|tyrosine-protein kinase JAK2
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Gene Info — Jak2
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Gene Info — Jak2
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Interactome
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Pathway
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Disease
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Publication Reference
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SHP-2 regulates SOCS-1-mediated Janus kinase-2 ubiquitination/degradation downstream of the prolactin receptor.
Ali S, Nouhi Z, Chughtai N, Ali S.
The Journal of Biological Chemistry 2003 Dec; 278(52):52021.
Application：IP, WB-Tr, Human, HC11, HEK 293, Nb2 cells.
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SHP-2 regulates SOCS-1-mediated Janus kinase-2 ubiquitination/degradation downstream of the prolactin receptor.
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