TGFB1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TGFB1.
Immunogen
A synthetic peptide corresponding to human TGFB1.
Host
Rabbit
Theoretical MW (kDa)
13
Reactivity
Human, Mouse, Rat
Specificity
This antibody recognizes ~13 KDa of TGFB1.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (0.1-1 ug/mL)
ELISA (0.01-0.1 ug/mL)
Immunoprecipitation (2-5 ug/mL)
Immunohistochemistry (2-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In TBS, pH 7.2 (BSA, 10% Proclin300)
Storage Instruction
Store at 4°C. For long term storage store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human placenta stained with TGFB1 polyclonal antibody (Cat # PAB12738) at 1 : 100 for 10 min at RT. Staining of formalin-fixed tissue requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — TGFB1
Entrez GeneID
7040Gene Name
TGFB1
Gene Alias
CED, DPD1, TGFB, TGFbeta
Gene Description
transforming growth factor, beta 1
Gene Ontology
HyperlinkGene Summary
TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA (MIM 190170) in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for this peptide. TGFB1, TGFB2 (MIM 190220), and TGFB3 (MIM 190230) all function through the same receptor signaling systems.[supplied by OMIM
Other Designations
TGF-beta 1 protein|diaphyseal dysplasia 1, progressive|transforming growth factor-beta 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Dehydromevalonolactone ameliorates liver fibrosis and inflammation by repressing activation of NLRP3 inflammasome.
Wei-Xiao Niu, Yun-Yang Bao, Na Zhang, Zhen-Ning Lu, Mao-Xu Ge, Yi-Ming Li, Yi Li, Ming-Hua Chen, Hong-Wei He.
Bioorganic Chemistry 2022 Jun; 127:105971.
Application:WB-Ce, Human, Rat, LX-2 cells, Rat liver.
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Costunolide represses hepatic fibrosis through WW domain-containing protein 2-mediated Notch3 degradation.
Ge MX, Liu HT, Zhang N, Niu WX, Lu ZN, Bao YY, Huang R, Yu DK, Shao RG, He HW.
British Journal of Pharmacology 2020 Jan; 177(2):372.
Application:WB-Ti, Rat, Rat livers.
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Rat embryonic fibroblasts improve reprogramming of human keratinocytes into induced pluripotent stem cells.
Linta L, Stockmann MC, Kleinhans KN, Boeckers A, Storch A, Zaehres H, Lin Q, Barbi G, Boeckers TM, Kleger A, Liebau S.
Stem Cells Dev 2011 Jun; 21:965.
Application:WB-Ce, Mouse, Rat, MEFs, REFs.
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Dehydromevalonolactone ameliorates liver fibrosis and inflammation by repressing activation of NLRP3 inflammasome.
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