PSAP polyclonal antibody
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More Files
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Western Blot (Cell lysate)
The whole cell lysate derived from human hepatoma HepG2 was immunoblotted PSAP polyclonal antibody (Cat # PAB12733) at 1 : 500.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PSAP.
Immunogen
A synthetic peptide corresponding to amino acids 300-360 of human PSAP.
Host
Rabbit
Theoretical MW (kDa)
70
Reactivity
Human
Specificity
This antibody recognizes ~70 KDa of human PSAP.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (0.1-1 ug/mL)
ELISA (0.01-0.1 ug/mL)
Immunoprecipitation (2-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In TBS, pH 7.2 (BSA, 10% Proclin300)
Storage Instruction
Store at 4°C. For long term storage store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Cell lysate)
The whole cell lysate derived from human hepatoma HepG2 was immunoblotted PSAP polyclonal antibody (Cat # PAB12733) at 1 : 500.Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — PSAP
Entrez GeneID
5660Gene Name
PSAP
Gene Alias
FLJ00245, GLBA, MGC110993, SAP1
Gene Description
prosaposin
Gene Ontology
HyperlinkGene Summary
This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
OTTHUMP00000019776|sphingolipid activator protein-1
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Interactome
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Pathway
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Disease
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Publication Reference
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Combined saposin C and D deficiencies in mice lead to a neuronopathic phenotype, glucosylceramide and alpha-hydroxy ceramide accumulation, and altered prosaposin trafficking.
Sun Y, Witte DP, Zamzow M, Ran H, Quinn B, Matsuda J, Grabowski GA.
Human Molecular Genetics 2007 Apr; 16(8):957.
Application：IF, IP, Mouse, Mouse fibroblasts.
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Combined saposin C and D deficiencies in mice lead to a neuronopathic phenotype, glucosylceramide and alpha-hydroxy ceramide accumulation, and altered prosaposin trafficking.
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