MMP7 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MMP7.
Immunogen
A synthetic peptide corresponding to C-terminus of human MMP7.
Host
Rabbit
Theoretical MW (kDa)
30
Reactivity
Human
Specificity
This antibody recognizes ~30 KDa of human MMP7 protein.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (0.1-1 ug/mL)
ELISA (0.01-0.1 ug/mL)
Immunoprecipitation (2-5 ug/mL)
Immunohistochemistry (2-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In TBS, pH 7.2 (BSA, 10% Proclin300)
Storage Instruction
Store at 4°C. For long term storage store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Cell lysate)
The protein derived from the whole cell lysate of MMP7 stimulated A-431 was resolved onto 12% SDS-PAGE, transferred to NC membrane, followed by an immunoblotting with MMP7 polyclonal antibody (Cat # PAB12712) at 1 : 1000.Immunohistochemistry
Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — MMP7
Entrez GeneID
4316Gene Name
MMP7
Gene Alias
MMP-7, MPSL1, PUMP-1
Gene Description
matrix metallopeptidase 7 (matrilysin, uterine)
Omim ID
178990Gene Ontology
HyperlinkGene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq
Other Designations
matrin|matrix metalloproteinase 7|matrix metalloproteinase 7 (matrilysin, uterine)|uterine matrilysin
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Interactome
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Pathway
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Disease
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Publication Reference
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Protein Kinase D2 Assembles a Multiprotein Complex at the Trans-Golgi Network to Regulate Matrix Metalloproteinase Secretion.
Eiseler T, Wille C, Koehler C, Illing A, Seufferlein T.
The Journal of Biological Chemistry 2016 Jan; 291(1):462.
Application:WB-Tr, Human, HEK 293T cells.
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Active matrilysin (MMP-7) in human pterygia: potential role in angiogenesis.
Di Girolamo N, Coroneo MT, Wakefield D.
Investigative Ophthalmology & Visual Science 2001 Aug; 42(9):1963.
Application:IHC-P, WB-Re, Human, Human pterygia, Recombinant protein.
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Protein Kinase D2 Assembles a Multiprotein Complex at the Trans-Golgi Network to Regulate Matrix Metalloproteinase Secretion.
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