MMP13 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MMP13.
Immunogen
A synthetic peptide corresponding to the hinge region of human MMP13.
Host
Rabbit
Theoretical MW (kDa)
60, 48
Reactivity
Human, Mouse, Rat
Specificity
This antibody recognizes ~60 and 48 KDa human MMP13.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (0.1-1 ug/mL)
ELISA (0.01-0.1 ug/mL)
Immunoprecipitation (2-5 ug/mL)
Immunohistochemistry (1:100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 ( Antibody stabilizer).
Storage Instruction
Store at 4°C for three month without detectable loss of activity. For long term storage, store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry
Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — MMP13
Entrez GeneID
4322Gene Name
MMP13
Gene Alias
CLG3
Gene Description
matrix metallopeptidase 13 (collagenase 3)
Gene Ontology
HyperlinkGene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq
Other Designations
collagenase 3|matrix metalloproteinase 13|matrix metalloproteinase 13 (collagenase 3)
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Interactome
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Disease
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Publication Reference
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Nitric oxide elicits functional MMP-13 protein-tyrosine nitration during wound repair.
Lizarbe TR, Garcia-Rama C, Tarin C, Saura M, Calvo E, Lopez JA, Lopez-Otin C, Folgueras AR, Lamas S, Zaragoza C.
FASEB Journal 2008 Sep; 22(9):3207.
Application:IP, WB, Bovine, Bovine aortic endothelial cells (BAECs).
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Nitric oxide elicits functional MMP-13 protein-tyrosine nitration during wound repair.
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