Rabbit polyclonal antibody raised against synthetic peptide of MMP13.
Immunogen:
A synthetic peptide corresponding to the hinge region of human MMP13.
Host:
Rabbit
Theoretical MW (kDa):
60, 48
Reactivity:
Human, Mouse, Rat
Specificity:
This antibody recognizes ~60 and 48 KDa human MMP13.
Form:
Liquid
Quality Control Testing:
Antibody Reactive Against Synthetic Peptide.
Recommend Usage:
Western Blot (0.1-1 ug/mL) ELISA (0.01-0.1 ug/mL) Immunoprecipitation (2-5 ug/mL) Immunohistochemistry (1:100) The optimal working dilution should be determined by the end user.
Storage Buffer:
In PBS, pH 7.2 ( Antibody stabilizer).
Storage Instruction:
Store at 4°C for three month without detectable loss of activity. For long term storage, store at -20°C to -80°C. Aliquot to avoid repeated freezing and thawing.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq