LRRK2 polyclonal antibody
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More Files
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Western Blot (Cell lysate)
The cell lysate derived from NIH/3T3 was immunoprobed by LRRK2 polyclonal antibody (Cat # PAB12701) at 1 : 500. An immunoreactive band is observed around ~285 kDa (1). This band is abolished by pre-incubation with immunizing peptide (2).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of LRRK2.
Immunogen
A synthetic peptide corresponding to C-terminus of human LRRK2.
Host
Rabbit
Theoretical MW (kDa)
285
Reactivity
Human
Specificity
This antibody recognizes ~285 KDa of human LRRK2.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (0.1-1 ug/mL)
ELISA (0.01-0.1 ug/mL)
Immunoprecipitation (2-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In TBS, pH 7.2 (BSA, 10% Proclin300)
Storage Instruction
Store at 4°C. For long term storage store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Cell lysate)
The cell lysate derived from NIH/3T3 was immunoprobed by LRRK2 polyclonal antibody (Cat # PAB12701) at 1 : 500. An immunoreactive band is observed around ~285 kDa (1). This band is abolished by pre-incubation with immunizing peptide (2).Immunohistochemistry
Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — LRRK2
Entrez GeneID
120892Gene Name
LRRK2
Gene Alias
AURA17, DARDARIN, PARK8, RIPK7, ROCO2
Gene Description
leucine-rich repeat kinase 2
Gene Ontology
HyperlinkGene Summary
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq
Other Designations
Parkinson disease (autosomal dominant) 8|augmented in rheumatoid arthritis 17
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Interactome
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Disease
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Publication Reference
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A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease.
Melrose HL, Kent CB, Taylor JP, Dachsel JC, Hinkle KM, Lincoln SJ, Mok SS, Culvenor JG, Masters CL, Tyndall GM, Bass DI, Ahmed Z, Andorfer CA, Ross OA, Wszolek ZK, Delldonne A, Dickson DW, Farrer MJ.
Neuroscience 2007 Jul; 147(4):1047.
Application：IF, IHC-P, WB, Human, Mouse, Brain from Human and Mouse.
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A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease.
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