FOXP2 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
FOXP2 polyclonal antibody (Cat # PAB12684) staining of mouse brain (Lane 1) and mouse lung (Lane 2) lysate at 2.5 ug/mL , RT 1 hour.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
FOXP2 polyclonal antibody (Cat # PAB12684) staining formalin-fixed paraffin-embedded mouse lung tissue (10 ug/mL).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of FOXP2.
Immunogen
A synthetic peptide corresponding to internal region of human FOXP2.
Host
Rabbit
Theoretical MW (kDa)
83
Reactivity
Human, Mouse, Rat
Specificity
This antibody recognizes ~83 KDa of FOXP2 protein.
Form
Liquid
Isotype
IgG
Recommend Usage
Western Blot (0.5-5 ug/mL)
ELISA (0.01-0.1 ug/mL)
Immunoprecipitation (2-5 ug/mL)
Immunohistochemistry (0.5-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (BSA, 10% Proclin300)
Storage Instruction
Store at 4°C. For long term storage store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Tissue lysate)
FOXP2 polyclonal antibody (Cat # PAB12684) staining of mouse brain (Lane 1) and mouse lung (Lane 2) lysate at 2.5 ug/mL , RT 1 hour.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
FOXP2 polyclonal antibody (Cat # PAB12684) staining formalin-fixed paraffin-embedded mouse lung tissue (10 ug/mL).Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — FOXP2
Entrez GeneID
93986Gene Name
FOXP2
Gene Alias
CAGH44, DKFZp686H1726, SPCH1, TNRC10
Gene Description
forkhead box P2
Gene Ontology
HyperlinkGene Summary
This gene encodes an evolutionarily conserved transcription factor expressed in fetal and adult brain. This transcription factor is a member of the forkhead/winged-helix (FOX) family of transcription factors, and contains a FOX DNA-binding domain and a large polyglutamine tract. Members of the FOX family of transcription factors are regulators of embryogenesis. The product of this gene is thought to be required for proper development of speech and language regions of the brain during embryogenesis. Although a point mutation in this gene has been associated with the KE pedigree segregating developmental verbal dyspraxia, no association between mutations in this gene and another speech disorder, autism, has been found. Multiple alternative transcripts encoding different isoforms have been identified. [provided by RefSeq
Other Designations
CAG repeat protein 44|OTTHUMP00000067772|forkhead/winged-helix transcription factor|speech and language disorder 1|trinucleotide repeat containing 10
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Interactome
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Disease
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Publication Reference
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Extrinsic Regulators of mRNA Translation in Developing Brain: Story of WNTs.
Yongkyu Park, Midori Lofton, Diana Li, Mladen-Roko Rasin.
Cells 2021 Jan; 10(2):253.
Application：IF, IHC, Mouse, Mouse brain, Mouse primary neuronal cells, N2a cells.
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Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors.
Lee Y, Katyal S, Downing SM, Zhao J, Russell HR, McKinnon PJ.
Nature Neuroscience 2012 Jun; 15(6):819.
Application：IF, IHC, Mouse, Mouse brain.
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ATR maintains select progenitors during nervous system development.
Lee Y, Shull ER, Frappart PO, Katyal S, Enriquez-Rios V, Zhao J, Russell HR, Brown EJ, McKinnon PJ.
The EMBO Journal 2012 Mar; 31(5):1177.
Application：IF, Mouse, Brain.
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A forkhead-domain gene is mutated in a severe speech and language disorder.
Lai CS, Fisher SE, Hurst JA, Vargha-Khadem F, Monaco AP.
Nature 2001 Oct; 413(6855):519.
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Extrinsic Regulators of mRNA Translation in Developing Brain: Story of WNTs.
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