DES polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of DES.
Immunogen
A synthetic peptide corresponding to residues surrounding T76/T77 of human DES.
Host
Rabbit
Theoretical MW (kDa)
55
Reactivity
Human, Mouse, Rat
Specificity
This antibody recognizes ~55 KDa of human DES without phosphorylated Thr76/Thr77. It does not recognize phosphorylated peptides confirmed by dot blot.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (0.1-1 ug/mL)
ELISA (0.01-0.1 ug/mL)
Immunoprecipitation (2-5 ug/mL)
Immunohistochemistry (2-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In TBS, pH 7.2 (BSA, 10% Proclin300)
Storage Instruction
Store at 4°C. For long term storage store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry
Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — DES
Entrez GeneID
1674Gene Name
DES
Gene Alias
CMD1I, CSM1, CSM2, FLJ12025, FLJ39719, FLJ41013, FLJ41793
Gene Description
desmin
Gene Ontology
HyperlinkGene Summary
This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq
Other Designations
OTTHUMP00000064865|intermediate filament protein
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Interactome
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Pathway
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Disease
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Publication Reference
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Protein kinase C-mediated desmin phosphorylation is related to myofibril disarray in cardiomyopathic hamster heart.
Huang X, Li J, Foster D, Lemanski SL, Dube DK, Zhang C, Lemanski LF.
Experimental Biology and Medicine (Maywood, N.J.) 2002 Dec; 227(11):1039.
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Protein kinase C phosphorylation of desmin at four serine residues within the non-alpha-helical head domain.
Kitamura S, Ando S, Shibata M, Tanabe K, Sato C, Inagaki M.
The Journal of Biological Chemistry 1989 Apr; 264(10):5674.
Application：WB-Ce, WB-Tr, Human, Mammalian cells.
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Protein kinase C-mediated desmin phosphorylation is related to myofibril disarray in cardiomyopathic hamster heart.
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