HPGD polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against HPGD.
Immunogen
Human HPGD.
Host
Rabbit
Reactivity
Human
Specificity
This antibody is specific to 15-PGDH.
Form
Liquid
Quality Control Testing
Antibody Reactive Against HPGD.
Recommend Usage
Western Blot (1:5000-1:6000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris-glycine, 150 mM NaCl (0.05% sodium azide)
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of HPGD in LoVo whole cell lysates using HPGD polyclonal antibody (Cat # PAB12548). Lane 1 uses a 1 : 6000 dilution. Lane 2 uses a 1 : 1500 dilution.Immunofluorescence
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Gene Info — HPGD
Entrez GeneID
3248Gene Name
HPGD
Gene Alias
15-PGDH, PGDH, PGDH1, SDR36C1
Gene Description
hydroxyprostaglandin dehydrogenase 15-(NAD)
Omim ID
601688Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
15-hydroxy prostaglandin dehydrogenase|15-hydroxyprostaglandin dehydrogenase|NAD+-dependent 15-hydroxyprostaglandin dehydrogenase|short chain dehydrogenase/reductase family 36C, member 1
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Interactome
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Disease
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Publication Reference
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Repression of prostaglandin dehydrogenase by epidermal growth factor and snail increases prostaglandin E2 and promotes cancer progression.
Mann JR, Backlund MG, Buchanan FG, Daikoku T, Holla VR, Rosenberg DW, Dey SK, DuBois RN.
Cancer Research 2006 Jul; 66(13):6649.
Application:WB, Human, HCT-15 cells.
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15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers.
Yan M, Rerko RM, Platzer P, Dawson D, Willis J, Tong M, Lawrence E, Lutterbaugh J, Lu S, Willson JK, Luo G, Hensold J, Tai HH, Wilson K, Markowitz SD.
PNAS 2004 Dec; 101(50):17468.
Application:IHC-P, WB-Ce, WB-Tr, Human, FET cells, Human colon cancer, Human normal mucosa, Vaco series colon cell lines.
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15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer.
Backlund MG, Mann JR, Holla VR, Buchanan FG, Tai HH, Musiek ES, Milne GL, Katkuri S, DuBois RN.
The Journal of Biological Chemistry 2004 Nov; 280(5):3217.
Application:WB-Ce, Human, HCT-15, HCT-116, HCA-7, LS-174T cells.
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NAD+-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) behaves as a tumor suppressor in lung cancer.
Ding Y, Tong M, Liu S, Moscow JA, Tai HH.
Carcinogenesis 2005 Jan; 26(1):65.
Application:WB, Human, A-549 cells.
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Differential changes in 15-hydroxyprostaglandin dehydrogenase and prostaglandin H synthase (types I and II) in human pregnant myometrium.
Giannoulias D, Patel FA, Holloway AC, Lye SJ, Tai HH, Challis JR.
The Journal of Clinical Endocrinology and Metabolism 2002 Mar; 87(3):1345.
Application:IF, IHC, WB-Ti, Human, Myometrial samples.
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Repression of prostaglandin dehydrogenase by epidermal growth factor and snail increases prostaglandin E2 and promotes cancer progression.
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