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Last updated: 2017/7/23
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VHL polyclonal antibody

  • Catalog # : PAB12546
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of VHL.
  • Immunogen:
  • A synthetic peptide corresponding to human and mouse VHL/Vhl.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Specificity:
  • This antibody is specific to VHL protein.
  • Form:
  • Liquid
  • Recommend Usage:
  • Western Blot (1:500-1:1000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In Tris-citrate/phosphate buffer, pH 7.0-8.0 (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. Do not freeze.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • Western blot analysis of VHL in human kidney samples (30 ug) using VHL polyclonal antibody (Cat # PAB12546). Lane 1 : 0.5 ug/mL primary. Lane 2 : 2 ug/mL primary.
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 7428
  • Gene Name:
  • VHL
  • Gene Alias:
  • HRCA1,RCA1,VHL1
  • Gene Description:
  • von Hippel-Lindau tumor suppressor
  • Gene Summary:
  • Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq
  • Other Designations:
  • elongin binding protein
  • Gene Information
  • Gene Name:
  • Vhl
  • Gene Alias:
  • Vhlh
  • Gene Description:
  • von Hippel-Lindau syndrome
  • Other Designations:
  • OTTMUSP00000028703,von Hippel-Lindau syndrome homolog,von Hippel-Lindau syndrome protein homolog
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