PTCH1 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PTCH1.
Immunogen
A synthetic peptide corresponding to amino acids 269-279 of human and mouse PTCH1/Ptch1.
Host
Rabbit
Theoretical MW (kDa)
161
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
ELISA (1:100-1:2000)
Immunocytochemistry/Immunofluorescence (1:10-1:500)
Immunohistochemistry (Frozen sections) (1:10-1:500)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:10-1:500)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide).
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of human PTCH1 in fetal brain lysate with PTCH1 polyclonal antibody (Cat # PAB12543) at a 1 : 500 dilution. -
Gene Info — PTCH1
Entrez GeneID
5727Gene Name
PTCH1
Gene Alias
BCNS, FLJ26746, FLJ42602, HPE7, NBCCS, PTC, PTC1, PTCH, PTCH11
Gene Description
patched homolog 1 (Drosophila)
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently. [provided by RefSeq
Other Designations
OTTHUMP00000021709|OTTHUMP00000021710|PTCH protein +12b|PTCH protein +4'|PTCH protein -10|patched
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Gene Info — Ptch1
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Interactome
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Pathway
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Disease
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Publication Reference
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Immunological characterization of chromatin assembly factor I, a human cell factor required for chromatin assembly during DNA replication in vitro.
Smith S, Stillman B.
The Journal of Biological Chemistry 1991 Jun; 266(18):12041.
Application:ICC, IP, WB-Ce, WB-Re, Human, HEK 293 cells, HeLa cells, Recombinant protein.
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Immunological characterization of chromatin assembly factor I, a human cell factor required for chromatin assembly during DNA replication in vitro.
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