Rabbit polyclonal antibody raised against synthetic peptide of PTCH1.
A synthetic peptide corresponding to amino acids 269-279 of human and mouse PTCH1/Ptch1.
Chicken, Human, Mouse, Rat
Quality Control Testing:
Antibody Reactive Against Synthetic Peptide.
ELISA (1:500-1:1000) Immunocytochemistry (1:500-1:1000) Immunohistochemistry (Frozen sections) (1:500-1:1000) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:500-1:1000) Western Blot (1:500-1:1000) The optimal working dilution should be determined by the end user.
In PBS (0.02% sodium azide)
Store at 4°C for short term. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently. [provided by RefSeq
OTTHUMP00000021709,OTTHUMP00000021710,PTCH protein +12b,PTCH protein +4',PTCH protein -10,patched