NR1H3/NR1H2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NR1H3/NR1H2.
Immunogen
A synthetic peptide corresponding to amino acids 50-150 of human NR1H3/NR1H2.
Host
Rabbit
Reactivity
Chicken, Human, Mouse, Primates, Rat
Specificity
This antibody is specific to LXR alpha and beta isoforms.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (0.5-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris-glycine, 150 mM NaCl (0.05% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of LXR in human liver using NR1H3/NR1H2 polyclonal antibody (Cat # PAB12535).Western Blot (Transfected lysate)
Western blot analysis of LXR in lysates of cells that were transfected with the pCMV6-ENTRY control or pCMV6-ENTRY NR1H3 cDNA using NR1H3/NR1H2 polyclonal antibody (Cat # PAB12535). -
Gene Info — NR1H2
Entrez GeneID
7376Gene Name
NR1H2
Gene Alias
LXR-b, LXRB, NER, NER-I, RIP15, UNR
Gene Description
nuclear receptor subfamily 1, group H, member 2
Omim ID
600380Gene Ontology
HyperlinkGene Summary
The LX receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize with retinoid X receptor (see MIM 180245) and bind to specific response elements (LXREs) characterized by direct repeats separated by 4 nucleotides. Two genes, alpha (LXRA, MIM 602423) and beta, are known to encode LXR proteins (Song et al., 1995 [PubMed 7625741]).[supplied by OMIM
Other Designations
LX receptor beta|liver X receptor beta|liver X receptor-beta|nuclear orphan receptor LXR-beta|oxysterols receptor LXR-beta|steroid hormone-nuclear receptor NER|ubiquitously-expressed nuclear receptor
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Gene Info — NR1H3
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Interactome
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Pathway
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Disease
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Publication Reference
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Suppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profile.
Dang H, Liu Y, Pang W, Li C, Wang N, Shyy JY, Zhu Y.
The Journal of Biological Chemistry 2009 Jan; 284(10):6218.
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Atorvastatin decreases lipoprotein lipase and endothelial lipase expression in human THP-1 macrophages.
Qiu G, Hill JS.
Journal of Lipid Research 2007 Oct; 48(10):2112.
Application:WB, Human, THP-1 cells.
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NO-1886 upregulates ATP binding cassette transporter A1 and inhibits diet-induced atherosclerosis in Chinese Bama minipigs.
Zhang C, Yin W, Liao D, Huang L, Tang C, Tsutsumi K, Wang Z, Liu Y, Li Q, Hou H, Cai M, Xiao J.
Journal of Lipid Research 2006 Sep; 47(9):2055.
Application:WB-Ti, Pig, Aorta, Liver, Retroperitoneal adipose tissue.
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Suppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profile.
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