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Last updated: 2017/3/26
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FANCD2 (phospho S222) polyclonal antibody

  • Catalog # : PAB12530
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic phosphopeptide of FANCD2.
  • Immunogen:
  • Synthetic phosphopeptide corresponding to residues surrounding S222 of human FANCD2.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Specificity:
  • This antibody is specific to the phosphorylated form of FANCD2.
  • Form:
  • Liquid
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • No additive
  • Storage Instruction:
  • Store at -20°C or -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Indicated lymphoblasts (PD7, WT : GM1526, AT) were irradiated with 15 Gy (2), and immunoblotted with anti-FANCD2 and FANCD2 (phospho S222) polyclonal antibody (Cat # PAB12530).
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • FA-D2 fibroblasts were stably transfected with either pMMP (empty vector, A), FANCD2 (wt, B), FANCD2 (S222A, C), FANCD2 (triple mutant, D), or FANCD2 (quadruple mutant, E). Cells were irradiated with 15 Gy (+), and whole cell lysates were immunoblotted with either anti-FANCD2 or Phospho-FANCD2 S222 polyclonal antibody, (Cat # PAB12530).
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 2177
  • Gene Name:
  • FANCD2
  • Gene Alias:
  • DKFZp762A223,FA-D2,FA4,FACD,FAD,FAD2,FANCD,FLJ23826
  • Gene Description:
  • Fanconi anemia, complementation group D2
  • Gene Summary:
  • The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq
  • Other Designations:
  • Fanconi anemia complementation group D2,type 4 Fanconi pancytopenia
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