MLXIPL polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MLXIPL.
Immunogen
A synthetic peptide corresponding to amino acids 50-150 of human MLXIPL.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
This antibody is specific to ChREBP.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Immunofluorescence (1:100-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris-citrate/phosphate buffer, pH 7.0-8.0 (0.01% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunofluorescence
Immunofluorescent staining of MLXIPL in human hepatocyte using MLXIPL polyclonal antibody (Cat # PAB12521). Overlay staining of MLXIPL (rhodamine red) and DAPI nuclear staining (blue). -
Gene Info — MLXIPL
Entrez GeneID
51085Gene Name
MLXIPL
Gene Alias
CHREBP, MIO, MONDOB, WBSCR14, WS-bHLH, bHLHd14
Gene Description
MLX interacting protein-like
Omim ID
605678Gene Ontology
HyperlinkGene Summary
This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. [provided by RefSeq
Other Designations
Mlx interactor|OTTHUMP00000160457|OTTHUMP00000160458|WS basic-helix-loop-helix leucine zipper protein|Williams Beuren syndrome chromosome region 14|carbohydrate response element binding protein|carbohydrate-responsive element-binding protein
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Interactome
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Disease
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Publication Reference
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Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis.
Iizuka K, Bruick RK, Liang G, Horton JD, Uyeda K.
PNAS 2004 May; 101(19):7281.
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Comparison of the expression and activity of the lipogenic pathway in human and rat adipose tissue.
Letexier D, Pinteur C, Large V, Fréring V, Beylot M.
Journal of Lipid Research 2003 Nov; 44(11):2127.
Application:WB, Human, Rat, Adipose tissues.
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A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver.
Yamashita H, Takenoshita M, Sakurai M, Bruick RK, Henzel WJ, Shillinglaw W, Arnot D, Uyeda K.
PNAS 2001 Jul; 98(16):9116.
Application:IHC-Fr, WB, Mouse , Mouse testicular germ cells.
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Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis.
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