MLXIPL polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of MLXIPL in liver nuclear extracts from well-fed rats. 7% SDS gel, 1 : 1,000 dilution of MLXIPL polyclonal antibody (Cat # PAB12520). Photo courtesy of Dr. Uyeda, UT Southwestern University.
Western Blot (Cell lysate)
Western blot analysis of MLXIPL in 20 ug of human hepatocyte lysate using MLXIPL polyclonal antibody (Cat # PAB12520). 5-10 second film exposure.
Immunofluorescence
Immunofluorescent staining of MLXIPL in human hepatocyte using MLXIPL polyclonal antibody (Cat # PAB12520). Overlay staining of MLXIPL (rhodamine red) and DAPI nuclear staining (blue).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MLXIPL.
Immunogen
A synthetic peptide corresponding to amino acids 800-852 of human MLXIPL.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to ChREBP.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Immunofluorescence (1:100-1:500)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris-citrate/phosphate buffer, pH 7.0-8.0 (0.01% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
ChIP
Western Blot (Tissue lysate)
Western blot analysis of MLXIPL in liver nuclear extracts from well-fed rats. 7% SDS gel, 1 : 1,000 dilution of MLXIPL polyclonal antibody (Cat # PAB12520). Photo courtesy of Dr. Uyeda, UT Southwestern University.Western Blot (Cell lysate)
Western blot analysis of MLXIPL in 20 ug of human hepatocyte lysate using MLXIPL polyclonal antibody (Cat # PAB12520). 5-10 second film exposure.Immunofluorescence
Immunofluorescent staining of MLXIPL in human hepatocyte using MLXIPL polyclonal antibody (Cat # PAB12520). Overlay staining of MLXIPL (rhodamine red) and DAPI nuclear staining (blue). -
Gene Info — MLXIPL
Entrez GeneID
51085Gene Name
MLXIPL
Gene Alias
CHREBP, MIO, MONDOB, WBSCR14, WS-bHLH, bHLHd14
Gene Description
MLX interacting protein-like
Omim ID
605678Gene Ontology
HyperlinkGene Summary
This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. [provided by RefSeq
Other Designations
Mlx interactor|OTTHUMP00000160457|OTTHUMP00000160458|WS basic-helix-loop-helix leucine zipper protein|Williams Beuren syndrome chromosome region 14|carbohydrate response element binding protein|carbohydrate-responsive element-binding protein
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Interactome
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Disease
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Publication Reference
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Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice.
Moon YA, Hammer RE, Horton JD.
Journal of Lipid Research 2009 Mar; 50(3):412.
Application：WB-Ti, Mouse, Mouse liver.
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Elevated hepatic fatty acid elongase-5 activity affects multiple pathways controlling hepatic lipid and carbohydrate composition.
Wang Y, Torres-Gonzalez M, Tripathy S, Botolin D, Christian B, Jump DB.
Journal of Lipid Research 2008 Jul; 49(7):1538.
Application：WB-Ti, Rat, Rat liver.
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The presence of distal and proximal promoters for rat mitochondrial glycerol-3-phosphate acyltransferase.
Aneja KK, Guha P, Shilpi RY, Chakraborty S, Schramm LM, Haldar D.
Archives of Biochemistry and Biophysics 2008 Feb; 470(1):35.
Application：ChIP, Rat, Rat liver cells (CRL-1442).
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Prenatal exposure to a low-protein diet programs disordered regulation of lipid metabolism in the aging rat.
Erhuma A, Salter AM, Sculley DV, Langley-Evans SC, Bennett AJ.
American Journal of Physiology. Endocrinology and Metabolism 2007 Jun; 292(6):E1702.
Application：WB-Ti, Rat, Rat liver.
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Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice.
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