P4HTM polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of human PHD4 using P4HTM polyclonal antibody (Cat # PAB12516). Samples : whole cell lysate from HeLa cells, normoxic and hypoxic, respectively.
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant P4HTM.
Immunogen
Recombinant protein corresponding to C-terminus of human P4HTM.
Host
Rabbit
Reactivity
Human
Specificity
This antibody is specific to prolyl hydroxylase 4.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris-citrate/phosphate buffer, pH 7.0-8.0 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of human PHD4 using P4HTM polyclonal antibody (Cat # PAB12516). Samples : whole cell lysate from HeLa cells, normoxic and hypoxic, respectively. -
Gene Info — P4HTM
Entrez GeneID
54681Protein Accession#
NP_808808.1Gene Name
P4HTM
Gene Alias
EGLN4, HIFPH4, P4H-TM, PH-4, PH4, PHD4
Gene Description
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
Gene Ontology
HyperlinkGene Summary
The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq
Other Designations
OTTHUMP00000082685|P4H with transmembrane domain|Prolyl hydroxlase domain-containing 4|hypoxia inducible factor prolyl 4 hydroxylase|hypoxia-inducible factor prolyl 4-hydroxylase|proline 4-hydroxylase
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Interactome
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Publication Reference
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Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor.
Ivan M, Haberberger T, Gervasi DC, Michelson KS, Gunzler V, Kondo K, Yang H, Sorokina I, Conaway RC, Conaway JW, Kaelin WG Jr.
PNAS 2002 Oct; 99(21):13459.
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Oxygen sensors and angiogenesis.
Maxwell PH, Ratcliffe PJ.
Seminars in Cell & Developmental Biology 2002 Feb; 13(1):29.
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A conserved family of prolyl-4-hydroxylases that modify HIF.
Bruick RK, McKnight SL.
Science 2001 Oct; 294(5545):1337.
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Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor.
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