Western blot analysis of whole bovine brain extract stained with UCHL1 polyclonal antibody (Cat # PAB12509) showing a strong and clean band at about 24kDa.
Shows rat mixed neuron/glial cultures stained with UCHL1 polyclonal antibody (Cat # PAB12509) (green). Blue is a DNA stain. Note that the UCHL1 stains neurons strongly and specifically, and that the staining is concentrated in the cell bodies, though some does extend into the dendrites also.
The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease