ABCG1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Detection of ABCG1 in mouse peritoneal macrophages (40 ug) using ABCG1 polyclonal antibody (Cat # PAB12503). Lane 1 : positive ABCG1 control, lane 2 : 10 uM 22- (R) -hydrocholesterol treated macrophages, Lane 3 : 100 nM T0901713 (LXRa ligand) treated macrophages, and Lane 4 : 500 nM T091713 (LXRa ligand) treated macrophages.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ABCG1.
Immunogen
A synthetic peptide corresponding to amino acids 300-400 of human ABCG1.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
The specificity of this antibody is for ABCG1.
Form
Liquid
Recommend Usage
Western Blot (1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris-citrate/phosphate buffer, pH 7.0-8.0 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Detection of ABCG1 in mouse peritoneal macrophages (40 ug) using ABCG1 polyclonal antibody (Cat # PAB12503). Lane 1 : positive ABCG1 control, lane 2 : 10 uM 22- (R) -hydrocholesterol treated macrophages, Lane 3 : 100 nM T0901713 (LXRa ligand) treated macrophages, and Lane 4 : 500 nM T091713 (LXRa ligand) treated macrophages.Immunohistochemistry
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Gene Info — ABCG1
Entrez GeneID
9619Protein Accession#
P45844Gene Name
ABCG1
Gene Alias
ABC8, MGC34313, WHITE1
Gene Description
ATP-binding cassette, sub-family G (WHITE), member 1
Omim ID
603076Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified. [provided by RefSeq
Other Designations
ABC transporter 8|ATP-binding cassette sub-family G member 1|ATP-binding cassette transporter 8|ATP-binding cassette transporter member 1 of subfamily G|OTTHUMP00000109322|homolog of Drosophila white|white protein homolog (ATP-binding cassette transporter
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Interactome
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Pathway
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Disease
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Publication Reference
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LXR-induced reverse cholesterol transport in human airway smooth muscle is mediated exclusively by ABCA1.
Delvecchio CJ, Bilan P, Nair P, Capone JP.
American Journal of Physiology. Lung Cellular and Molecular Physiology 2008 Nov; 295(5):L949.
Application：WB-Tr, Human, hASM cells.
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ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo.
Burgess BL, Parkinson PF, Racke MM, Hirsch-Reinshagen V, Fan J, Wong C, Stukas S, Theroux L, Chan JY, Donkin J, Wilkinson A, Balik D, Christie B, Poirier J, Lutjohann D, Demattos RB, Wellington CL.
Journal of Lipid Research 2008 Jun; 49(6):1254.
Application：WB-Ti, Mouse, Mouse brain.
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The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of beta-amyloid precursor protein.
Tansley GH, Burgess BL, Bryan MT, Su Y, Hirsch-Reinshagen V, Pearce J, Chan JY, Wilkinson A, Evans J, Naus KE, McIsaac S, Bromley K, Song W, Yang HC, Wang N, DeMattos RB, Wellington CL.
Journal of Lipid Research 2007 May; 48(5):1022.
Application：WB-Tr, Human, HEK 293 cells.
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Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathways.
Wang MD, Kiss RS, Franklin V, McBride HM, Whitman SC, Marcel YL.
Journal of Lipid Research 2007 Mar; 48(3):633.
Application：WB, Mouse, Mouse macrophages.
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Decreased atherosclerosis in low-density lipoprotein receptor knockout mice transplanted with Abcg1-/- bone marrow.
Ranalletta M, Wang N, Han S, Yvan-Charvet L, Welch C, Tall AR.
Arteriosclerosis, Thrombosis, and Vascular Biology 2006 Oct; 26(10):2308.
Application：WB, Mouse, Mouse macrophages.
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LXR-induced reverse cholesterol transport in human airway smooth muscle is mediated exclusively by ABCA1.
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