ABCG8 polyclonal antibody
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More Files
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Western Blot
Western blot analysis of ABCG8 using ABCG8 polyclonal antibody (Cat # PAB12501). Samples : mouse liver microsomes from G5/G8 knockout mice (lane 1), wildtype human G5/G8 (Lane 2), and transgenic human G5/G8 (lane 3).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ABCG8.
Immunogen
A synthetic peptide corresponding to N-terminus of human ABCG8.
Host
Rabbit
Reactivity
Human
Specificity
Specific for ABCG8.
Form
Liquid
Recommend Usage
Western Blot (1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of ABCG8 using ABCG8 polyclonal antibody (Cat # PAB12501). Samples : mouse liver microsomes from G5/G8 knockout mice (lane 1), wildtype human G5/G8 (Lane 2), and transgenic human G5/G8 (lane 3). -
Gene Info — ABCG8
Entrez GeneID
64241Protein Accession#
Q9H221Gene Name
ABCG8
Gene Alias
GBD4, MGC142217, STSL
Gene Description
ATP-binding cassette, sub-family G (WHITE), member 8
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions to exclude non-cholesterol sterol entry at the intestinal level, promote excretion of cholesterol and sterols into bile, and to facilitate transport of sterols back into the intestinal lumen. It is expressed in a tissue-specific manner in the liver, intestine, and gallbladder. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq
Other Designations
ATP-binding cassette sub-family G member 8|ATP-binding cassette, subfamily G, member 8|sterolin 2
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Interactome
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Pathway
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Disease
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Publication Reference
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Regulation of intestinal NPC1L1 expression by dietary fish oil and docosahexaenoic acid.
Mathur SN, Watt KR, Field FJ.
Journal of Lipid Research 2007 Feb; 48(2):395.
Application：WB, Human, CaCo-2 cells.
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Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1.
Kobayashi A, Takanezawa Y, Hirata T, Shimizu Y, Misasa K, Kioka N, Arai H, Ueda K, Matsuo M.
Journal of Lipid Research 2006 Aug; 47(8):1791.
Application：WB-Tr, Human, HEK 293 cells.
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Comparative genome analysis of potential regulatory elements in the ABCG5-ABCG8 gene cluster.
Remaley AT, Bark S, Walts AD, Freeman L, Shulenin S, Annilo T, Elgin E, Rhodes HE, Joyce C, Dean M, Santamarina-Fojo S, Brewer HB Jr.
Biochemical and Biophysical Research Communications 2002 Jul; 295(2):276.
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Role of ABCG1 and other ABCG family members in lipid metabolism.
Schmitz G, Langmann T, Heimerl S.
J Lipid Res 2001 Oct; 42(10):1513.
Application：IHC, WB, Human, Livers, Small intestine.
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Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein.
Garcia CK, Wilund K, Arca M, Zuliani G, Fellin R, Maioli M, Calandra S, Bertolini S, Cossu F, Grishin N, Barnes R, Cohen JC, Hobbs HH.
Science 2001 May; 292(5520):1394.
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Regulation of intestinal NPC1L1 expression by dietary fish oil and docosahexaenoic acid.
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