ARNTL polyclonal antibody
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More Files
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Immunoprecipitation
Lanes 1-3 contained ARNTL immunoprecipitated DNA (60, 40 & 20 uL of antisera respectively). ARNTL polyclonal antibody (Cat # PAB12484) was used.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant ARNTL.
Immunogen
Recombinant protein corresponding to human ARNTL.
Host
Rabbit
Reactivity
Human
Specificity
This antibody is specific to MOP3/BMAL1.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
Western Blot (1:100-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
ChIP
Western Blot
Immunoprecipitation
Lanes 1-3 contained ARNTL immunoprecipitated DNA (60, 40 & 20 uL of antisera respectively). ARNTL polyclonal antibody (Cat # PAB12484) was used. -
Gene Info — ARNTL
Entrez GeneID
406Protein Accession#
O00327Gene Name
ARNTL
Gene Alias
BMAL1, BMAL1c, JAP3, MGC47515, MOP3, PASD3, TIC, bHLHe5
Gene Description
aryl hydrocarbon receptor nuclear translocator-like
Omim ID
602550Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This complex binds an E-box upstream of the PER1 gene, activating this gene and possibly other circadian rhythym-associated genes. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq
Other Designations
ARNT-like protein 1, brain and muscle|bHLH-PAS protein JAP3|basic-helix-loop-helix-PAS orphan MOP3|member of PAS superfamily 3
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Interactome
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Pathway
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Disease
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Publication Reference
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Mop3 is an essential component of the master circadian pacemaker in mammals.
Bunger MK, Wilsbacher LD, Moran SM, Clendenin C, Radcliffe LA, Hogenesch JB, Simon MC, Takahashi JS, Bradfield CA.
Cell 2000 Dec; 103(7):1009.
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Antiphase circadian expression between BMAL1 and period homologue mRNA in the suprachiasmatic nucleus and peripheral tissues of rats.
Oishi K, Sakamoto K, Okada T, Nagase T, Ishida N.
Biochemical and Biophysical Research Communications 1998 Dec; 253(2):199.
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Role of the CLOCK protein in the mammalian circadian mechanism.
Gekakis N, Staknis D, Nguyen HB, Davis FC, Wilsbacher LD, King DP, Takahashi JS, Weitz CJ.
Science 1998 Jun; 280(5369):1564.
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Mop3 is an essential component of the master circadian pacemaker in mammals.
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