ATP7B polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ATP7B.
Immunogen
A synthetic peptide corresponding to C-terminus of human ATP7B.
Host
Rabbit
Reactivity
Human
Specificity
This antibody is specific to ATPb7.
Form
Liquid
Recommend Usage
Immunocytochemistry/Immunofluorescence (1:10-1:2000)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris-citrate/phosphate buffer, pH 7.0-8.0 (0.09% sodium azide).
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
This antibody is useful for Immunocytochemistry/Immunofluorescence and Western blot. By WB, this antibody recognizes a band at 165 kDa, representing ATP7b. This antibody also recognizes a band at ~220 kDa. This antibody may work on endogenous protein in immunohistochemistry, but it has only been tested on transfected ovarian carcinoma cells at a 1:500 dilution. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. -
Applications
Western Blot
Immunocytochemistry
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Gene Info — ATP7B
Entrez GeneID
540Protein Accession#
P35670Gene Name
ATP7B
Gene Alias
PWD, WC1, WD, WND
Gene Description
ATPase, Cu++ transporting, beta polypeptide
Gene Ontology
HyperlinkGene Summary
This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD). [provided by RefSeq
Other Designations
ATPase, Cu(2+)- transporting, beta polypeptide|OTTHUMP00000040880|Wilson disease-associated protein|copper pump 2|copper-transporting ATPase 2
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Interactome
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Disease
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Publication Reference
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NH2-terminal signals in ATP7B Cu-ATPase mediate its Cu-dependent anterograde traffic in polarized hepatic cells.
Guo Y, Nyasae L, Braiterman LT, Hubbard AL.
American Journal of Physiology. Gastrointestinal and Liver Physiology 2005 Nov; 289(5):G904.
Application：IF, WB-Tr, Human, WIF-B cells.
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NH2-terminal signals in ATP7B Cu-ATPase mediate its Cu-dependent anterograde traffic in polarized hepatic cells.
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