ATP7B polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of ATP7B in 20 ug of mouse brain membrane fraction using ATP7B polyclonal antibody (Cat # PAB12477).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ATP7B.
Immunogen
A synthetic peptide corresponding to N-terminus of human ATP7B.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
This antibody is specific to ATP7b.
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In Tris-citrate/phosphate buffer, pH 7.0-8.0 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of ATP7B in 20 ug of mouse brain membrane fraction using ATP7B polyclonal antibody (Cat # PAB12477).Immunohistochemistry
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Gene Info — ATP7B
Entrez GeneID
540Protein Accession#
P35670Gene Name
ATP7B
Gene Alias
PWD, WC1, WD, WND
Gene Description
ATPase, Cu++ transporting, beta polypeptide
Gene Ontology
HyperlinkGene Summary
This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD). [provided by RefSeq
Other Designations
ATPase, Cu(2+)- transporting, beta polypeptide|OTTHUMP00000040880|Wilson disease-associated protein|copper pump 2|copper-transporting ATPase 2
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Interactome
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Disease
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Publication Reference
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Transport of cisplatin by the copper efflux transporter ATP7B.
Safaei R, Otani S, Larson BJ, Rasmussen ML, Howell SB.
Molecular Pharmacology 2008 Feb; 73(2):461.
Application：WB, Insects, Sf9 cells.
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Transport of cisplatin by the copper efflux transporter ATP7B.
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