CBX5 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of CBX5 in HeLa whole cell lysate using CBX5 polyclonal antibody (Cat # PAB12465).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CBX5.
Immunogen
A synthetic peptide corresponding to amino acids 1-100 of human CBX5.
Host
Rabbit
Reactivity
Human
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of CBX5 in HeLa whole cell lysate using CBX5 polyclonal antibody (Cat # PAB12465). -
Gene Info — CBX5
Entrez GeneID
23468Protein Accession#
P45973Gene Name
CBX5
Gene Alias
HP1, HP1A
Gene Description
chromobox homolog 5 (HP1 alpha homolog, Drosophila)
Omim ID
604478Gene Ontology
HyperlinkGene Summary
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq
Other Designations
HP1-ALPHA|HP1Hs alpha|antigen p25|heterochromatin protein 1 homolog alpha|heterochromatin protein 1-alpha
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Interactome
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Publication Reference
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Rb targets histone H3 methylation and HP1 to promoters.
Nielsen SJ, Schneider R, Bauer UM, Bannister AJ, Morrison A, O'Carroll D, Firestein R, Cleary M, Jenuwein T, Herrera RE, Kouzarides T.
Nature 2001 Aug; 412(6846):561.
Application：ChIP, Mouse, MEFs.
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Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain.
Bannister AJ, Zegerman P, Partridge JF, Miska EA, Thomas JO, Allshire RC, Kouzarides T.
Nature 2001 Mar; 410(6824):120.
Application：IF, Human, U2OS cells.
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Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
Lachner M, O'Carroll D, Rea S, Mechtler K, Jenuwein T.
Nature 2001 Mar; 410(6824):116.
Application：IF, Mouse, Primary mouse embryonic fibroblasts.
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Rb targets histone H3 methylation and HP1 to promoters.
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