CD36 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CD36.
Immunogen
A synthetic peptide corresponding to amino acids 100-200 of human CD36.
Host
Rabbit
Reactivity
Bovine, Human, Mouse, Primates, Rat
Form
Liquid
Recommend Usage
Immunocytochemistry (1:50-1:200)
Immunofluorescence (1:50-1:200)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200-1:400)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS buffer (0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Detection of CD36 in human adipocyte extract (30 ug) using CD36 polyclonal antibody (Cat # PAB12463). Lane 1 : 0.5 ug/mL ; lane 2 : 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry
Staining of CD36 on human adipocytes using CD36 polyclonal antibody (Cat # PAB12463) .Immunocytochemistry
Immunofluorescence
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Gene Info — CD36
Entrez GeneID
948Protein Accession#
P16671Gene Name
CD36
Gene Alias
CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3
Gene Description
CD36 molecule (thrombospondin receptor)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
CD36 antigen|CD36 antigen (collagen type I receptor, thrombospondin receptor)|PAS-4 protein|cluster determinant 36|fatty acid translocase|glycoprotein IIIb|leukocyte differentiation antigen CD36|platelet glycoprotein IV|scavenger receptor class B, member
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Interactome
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Pathway
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Disease
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Publication Reference
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The activated CD36-Src axis promotes lung adenocarcinoma cell proliferation and actin remodeling-involved metastasis in high-fat environment
Li-Zhong Liu, Bowen Wang, Rui Zhang, Zangshu Wu, Yuxi Huang, Xiaoyang Zhang, Jiaying Zhou, Junbo Yi, Jian Shen, Ming-Yue Li, Ming Dong.
Cell Death & Disease 2023 Aug; 14(8):548.
Application:IHC, Mouse, Mouse lung.
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Lipid oversupply induces CD36 sarcolemmal translocation via dual modulation of PKCζ and TBC1D1: an early event prior to insulin resistance.
Zhu B, Li MY, Lin Q, Liang Z, Xin Q, Wang M, He Z, Wang X, Wu X, Chen GG, Tong PC, Zhang W, Liu LZ.
Theranostics 2020 Jan; 10(3):1332.
Application:IF, WB-Ti, Mouse, L6 muscle cells, Mouse skeletal muscle.
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Lipolysis in Brown Adipocytes Is Not Essential for Cold-Induced Thermogenesis in Mice.
Shin H, Ma Y, Chanturiya T, Cao Q, Wang Y, Kadegowda AKG, Jackson R, Rumore D, Xue B, Shi H, Gavrilova O, Yu L.
Cell Metabolism 2017 Nov; 26(5):764.
Application:WB-Ti, Mouse, Mouse brown adipose tissues.
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The activated CD36-Src axis promotes lung adenocarcinoma cell proliferation and actin remodeling-involved metastasis in high-fat environment
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