CYP46A1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of CYP46A1 in human brain lysates using CYP46A1 polyclonal antibody (Cat # PAB12452).
Western Blot (Transfected lysate)
Western analysis of CYP46A1 in HEK293 cells overexpressing CYP46A1 or transfected with an empty vector using CYP46A1 polyclonal antibody (Cat #PAB12452).
Immunohistochemistry
Detection of CYP46A1 in human cortex using CYP46A1 polyclonal antibody (Cat # PAB12452).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CYP46A1.
Immunogen
A synthetic peptide corresponding to amino acids 200-250 of human CYP46A1.
Host
Rabbit
Reactivity
Human
Specificity
This antibody is specific to Cyp46.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In antiserum
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Tissue lysate)
Western blot analysis of CYP46A1 in human brain lysates using CYP46A1 polyclonal antibody (Cat # PAB12452).Western Blot (Transfected lysate)
Western analysis of CYP46A1 in HEK293 cells overexpressing CYP46A1 or transfected with an empty vector using CYP46A1 polyclonal antibody (Cat #PAB12452).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry
Detection of CYP46A1 in human cortex using CYP46A1 polyclonal antibody (Cat # PAB12452). -
Gene Info — CYP46A1
Entrez GeneID
10858Protein Accession#
Q9Y6A2Gene Name
CYP46A1
Gene Alias
CP46, CYP46
Gene Description
cytochrome P450, family 46, subfamily A, polypeptide 1
Omim ID
604087Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq
Other Designations
cholesterol 24-hydroxylase|cytochrome P450, family 46|cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase)
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Interactome
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Pathway
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Disease
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Publication Reference
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Differential expression of cholesterol hydroxylases in Alzheimer's disease.
Brown J 3rd, Theisler C, Silberman S, Magnuson D, Gottardi-Littell N, Lee JM, Yager D, Crowley J, Sambamurti K, Rahman MM, Reiss AB, Eckman CB, Wolozin B.
The Journal of Biological Chemistry 2004 Aug; 279(33):34674.
Application：IHC, WB-Tr, Human, Frontal cortex from patients with Alzheimer's Disease, HEK 293 cells.
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Differential expression of cholesterol hydroxylases in Alzheimer's disease.
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