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Last updated: 2017/2/19
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CYP46A1 polyclonal antibody

  • Catalog # : PAB12452
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of CYP46A1.
  • Immunogen:
  • A synthetic peptide corresponding to amino acids 200-250 of human CYP46A1.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Specificity:
  • This antibody is specific to Cyp46.
  • Form:
  • Liquid
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • Western Blot (1:1000)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In antiserum
  • Storage Instruction:
  • Store at 4°C for short term. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Publication Reference
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • Western blot analysis of CYP46A1 in human brain lysates using CYP46A1 polyclonal antibody (Cat # PAB12452).
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • Western analysis of CYP46A1 in HEK293 cells overexpressing CYP46A1 or transfected with an empty vector using CYP46A1 polyclonal antibody (Cat #PAB12452).
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry
  • Immunohistochemistry
  • Detection of CYP46A1 in human cortex using CYP46A1 polyclonal antibody (Cat # PAB12452).
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Gene Information
  • Gene Name:
  • CYP46A1
  • Gene Alias:
  • CP46,CYP46
  • Gene Description:
  • cytochrome P450, family 46, subfamily A, polypeptide 1
  • Gene Summary:
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq
  • Other Designations:
  • cholesterol 24-hydroxylase,cytochrome P450, family 46,cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase)
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